文献类型：期刊文献

英文题名：Gender differences in triglyceride glucose index predictive power for type 2 diabetes mellitus: a Chinese cohort study

作者：Guo, Rubing[1,2,3];Tong, Jingjing[4];Wang, Ruirui[1];Ma, Songtai[1];Wei, Lianhua[3];Zhao, Wei[2]

第一作者：Guo, Rubing

通信作者：Zhao, W[1];Wei, LH[2]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Peoples R China;[2]China Japan Friendship Hosp, Dept Clin Lab, 2 Yinghuayuan East St, Beijing 100029, Peoples R China;[3]Gansu Prov Hosp, Dept Centrol Lab, 204 West Donggang Rd, Lanzhou 730000, Gansu, Peoples R China;[4]China Japan Friendship Hosp, Dept Infect Dis, Beijing 100029, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), China Japan Friendship Hosp, Dept Clin Lab, 2 Yinghuayuan East St, Beijing 100029, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Centrol Lab, 204 West Donggang Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2024

外文期刊名：INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES

收录：;Scopus(收录号：2-s2.0-85197489605);WOS:【SCI-EXPANDED(收录号:WOS:001263311500001)】；

基金：This work was supported by the National High Level Hospital Clinical Research Funding (grant number 2023-NHLHCRF-PY-04); the Wu Jieping Medical Foundation (grant number 320.6750.2023-06-60); and the Research Projects of Gansu Provincial Hospital (grant number 23GSSYD-25).

语种：英文

外文关键词：Triglyceride glucose index; Type 2 diabetes mellitus; Sex differences; Insulin resistance; Predictive capability

摘要：Objective This study aims to explore the association between the triglyceride glucose (TyG) index and type 2 diabetes mellitus (T2DM) in Chinese men and women while assessing its predictive capability by gender. Methods Data from the DRYAD database were used in this study, which also performed a secondary analysis of 48,230 participants from the China Rui-Ci group. Data on lifestyle habits, detailed health indicators, and demographics were gathered. The TyG index was calculated, and statistical techniques such as multivariate Cox regression and generalized additive models were used to analyze the correlation between the TyG index and the incidence of T2DM. Gender-specific predictive capacity was evaluated through subgroup analyses and receiver operating characteristic curves (ROC). Results A cohort of 48,230 individuals demonstrated a significant positive link between the TyG index and T2DM risk in both genders. In the adjusted model, T2DM risk rose by 1.68 times (95% CI, 1.23-2.28) in males and 3.59 times (95% CI, 2.29-5.65) in females. Female participants showed a higher TyG index predictive value for T2DM (AUC = 0.812) compared to males (AUC = 0.721). Notably, females with hypertension displayed significantly elevated T2DM risk in various age groups compared to males (p for interaction < 0.05). Conclusion The study reveals a positive correlation between the TyG index and T2DM risk in both genders. Moreover, the predictive capacity of this relationship is notably stronger in females.