文献类型：期刊文献

中文题名：消定膏外敷联合“柔筋养精”手法治疗早中期膝骨关节炎临床研究

英文题名：Clinical study on the treatment of early and medium stages of knee osteoarthritis with the Xiao-Ding Ointment and'Roujin Yangjing'manipulative therapy

作者：董万涛[1];张乾军[1];宋敏[2];巩彦龙[2];张洁[1];刘保健[1]

第一作者：董万涛

机构：[1]甘肃中医药大学附属医院关节外科,兰州730020;[2]甘肃中医药大学中医临床学院,兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2021

卷号：36

期号：7

起止页码：4368

中文期刊名：中华中医药杂志

外文期刊名：China Journal of Traditional Chinese Medicine and Pharmacy

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：甘肃省卫生行业科研计划重大项目课题(NO.GSWST2013-05);甘肃中医药大学附属医院科研及技术创新基金青年项目。

语种：中文

中文关键词：膝骨关节炎;消定膏;“柔筋养精”手法;临床研究

外文关键词：Knee osteoarthritis(KOA);Xiao-Ding Ointment;Roujin Yangjing,manipulative;Clinical study

摘要：目的:观察消定膏外敷联合"柔筋养精"手法对早中期膝骨关节炎(KOA)的临床疗效,评价不同方法对早中期KOA的有效性和安全性。方法:将符合早中期KOA诊断标准的受试者315例,随机分为消定膏组、手法组、联合组,各105例。给予相应的治疗后对3组患者进行安全性评价,以VAS疼痛评分、WOMAC指数评分作为临床疗效评价指标。结果:3组患者在治疗中均无严重的不良反应;3组患者在治疗2、4周后VAS评分、WOMAC指数均较治疗前显著降低(P<0.05),组间比较,联合组对VAS评分、WOMAC指数改善优于消定膏组和手法组(P<0.05),联合组治疗2周后总有效率95.24%(100/105)显著高于消定膏组84.76%(89/105)和手法组82.86%(87/105)(P<0.05),联合组治疗4周后总有效率优于其他两组(P<0.05);联合组治疗4周后与治疗2周后比较总有效率差异无统计学意义;3~6个月随访后联合组复发率14.89%(7/47)显著低于手法组46.81%(22/47)和消定膏组38.30%(18/47)(P<0.05)。结论:消定膏外敷联合"柔筋养精"手法治疗早中期KOA安全、简便,能有效地缓解早中期KOA患者的临床症状,改善膝关节功能活动。
Objective:To observe the clinical effects of the external application of Xiao-Ding Ointment combined with the‘Roujin Yangjing’manipulative therapy in treating early and middle stage knee osteoarthritis(KOA).And evaluate the efficacy and safety of different therapy on early and middle stage KOA.Methods:All 315 patients with clinical early and middle stage KOA were randomly divided into Xiao-Ding Ointment group,manipulation group and combination group,105 cases each group,after the corresponding treatment,the safety of the three groups was evaluated,VAS pain score and WOMAC osteoarthritis index score were used as the clinical efficacy evaluation index.Results:There were no serious adverse reactions in the three groups;after 2 and 4 weeks of treatment,VAS score and WOMAC index of the three groups were significantly lower than those before treatment(P<0.05),compared with the Xiao-Ding Ointment group and the manipulation group,the combined group had a better improvement of VAS score and WOMAC index(P<0.05).After 2 weeks of treatment,the total effective rate of the combined group was 95.24%(100/105),which was significantly higher than 84.76%(89/105)of the Xiao-Ding Ointment group and 82.86%(87/105)of the manipulation group(P<0.05).After 4 weeks of treatment,the total effective rate of the combined group was better than the other two groups(P<0.05);there was no statistically significant difference in the total effective rate between the combined group after 4 weeks of treatment and after 2 weeks of treatment.After 3 to 6 months of follow-up visits,the recurrence rate of the combined group[14.89%(7/74)]was significantly lower than that of the manipulation group[48.81%(22/47)]and the Xiao-Ding Ointment group[38.30%(18/47)](P<0.05).Conclusion:The external application of Xiao-Ding Ointment combined with the‘Roujin Yangjing’manipulative therapy is a safe and simple treatment for early and middle stage KOA,it can effectively alleviate the clinical symptoms of early and middle stage KOA patients and improve the functional activities of knee joint.