文献类型：期刊文献

中文题名：2013-2021年中国≥40岁居民阿尔茨海默病死亡趋势分析

英文题名：Trend analysis of Alzheimer's disease deaths in residents aged≥40 years in China,2013?2021

作者：汪娆娆[1];裴文辉[1];李宏娥[1];王云超[2];杨震[1];任晓岚[3];王新华[1]

第一作者：汪娆娆

机构：[1]甘肃中医药大学公共卫生学院,甘肃兰州730000;[2]甘肃中医药大学基础医学院,甘肃兰州730000;[3]甘肃省疾病预防控制中心社区卫生与慢性病预防控制科,甘肃兰州730020

第一机构：甘肃中医药大学公共卫生学院

年份：2024

卷号：39

期号：8

起止页码：1033

中文期刊名：疾病监测

外文期刊名：Disease Surveillance

收录：CSTPCD;;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家重点研发计划“精准医学研究”重点专项(No.2017YFC0907202);中央引导地方科技发展资金项目(No.22ZY1QA003);2022年甘肃省高等学校产业支撑计划项目(No.2022CYZC-53);甘肃中医药大学研究生创新创业项目。

语种：中文

中文关键词：阿尔茨海默病;死亡率;趋势分析

外文关键词：Alzheimer's disease;Mortality;Trend analysis

摘要：目的 了解2013-2021年中国≥40岁居民阿尔茨海默病死亡率及其变化趋势,为进一步制定阿尔茨海默病防控措施提供依据。方法 收集《全国疾病监测系统死因监测数据集(2013-2021)》中分年龄段、性别、城乡和地区的阿尔茨海默病死亡数据和人口资料,计算粗死亡率并用2010年人口普查数据进行标化,通过粗死亡率和标化死亡率描述阿尔茨海默病的死亡状况,采用Joinpoint回归分析模型分析其变化趋势,组间死亡率的比较采用χ^(2)检验。结果 2013-2021年中国≥40岁年龄组居民阿尔茨海默病累计死亡130 517例,粗死亡率呈逐年上升趋势[平均年度变化百分比(AAPC)=4.36,P<0.001]。男性和女性的阿尔茨海默病粗死亡率均呈逐年上升趋势(AAPC=4.07%,AAPC=4.53%,P<0.001),女性粗死亡率和标化死亡率均高于男性(χ^(2)=2 029.970,χ^(2)=9 017.000,均P<0.001)。随年龄的增长,≥40岁年龄组居民的阿尔茨海默病标化死亡率呈上升趋势(AAPC=149.59%,P<0.001),其中≥80岁年龄组粗死亡率呈逐年上升趋势(AAPC=2.12%,P=0.021),40~49、50~59、60~69和70~79岁年龄组无明显趋势变化(均P>0.05)。城市和农村居民阿尔茨海默病粗死亡率均呈上升趋势(AAPC=3.43%,AAPC=4.73%,均P<0.001),农村居民死亡率和标化死亡率均高于城市居民(χ^(2)=640.360,χ^(2)=621.440,均P<0.001)。东部、中部和西部地区阿尔茨海默病粗死亡率均呈上升趋势(AAPC=2.59%,AAPC=6.11%,AAPC=6.66%,均P<0.001),东部地区粗死亡率和标化死亡率均高于西部地区(χ^(2)=10 766.460,P<0.001),西部地区高于中部地区(χ^(2)=34 720.920,P<0.001)。结论 2013-2021年中国≥40岁年龄组居民阿尔茨海默病死亡率呈逐年上升趋势。阿尔茨海默病死亡率存在性别,年龄别,城乡和地区差异。女性、老年人群、农村和东部地区居民是高危人群,需给予重点的预防与控制。
Objective To understand the mortality rate of Alzheimer's disease and its trends in residents aged≥40 years in China from 2013 to 2021,and provide evidence for the further improvement of Alzheimer's disease prevention and control.Methods The mortality data of Alzheimer's disease and demographic information of death cases in different age,gender,urban/rural status groups and regions in China were collected from the Death Cause Surveillance Dataset of National Disease Surveillance System(2013?2021),the crude mortality rate was calculated and standardized with 2010 census data to descriptive the Alzheimer's disease mortality,the mortality trend was analyzed by using Joinpoint regression model,and the comparison of the mortality rates among groups was performed with χ^(2) test.Results A total of 130517 Alzheimer's disease deaths in residents aged≥40 years were reported in China from 2013 to 2021.The crude mortality rate showed an increasing trend year by year[average annual percent change(AAPC)=4.36%,P<0.001],and the crude mortality rates in both men and women showed increasing trends year by year(AAPC=4.07%,P<0.001;AAPC=4.53%,P<0.001),and the crude and standardized mortality rates of Alzheimer's disease were higher in women than in men(χ^(2)=2029.970,P<0.001;χ^(2)=9017.000,P<0.001).The standardized mortality rate of Alzheimer's disease in residents aged≥40 years tended to increase with age(AAPC=149.59%,P<0.001).The crude mortality rate in age group≥80 years showed an increasing trend year by year(AAPC=2.12%,P=0.021),and there was no significant change in trend of Alzheimer's disease mortality among age groups 40–49 years,50–59 years,60–69 years and 70–79 years(P>0.05).The crude mortality rates of Alzheimer's disease showed increasing trends in both urban and rural residents(AAPC=3.43%,P<0.001;AAPC=4.73%,P<0.001),and the crude mortality rate and standardized mortality rate were higher in rural residents than in urban residents(χ^(2)=640.360,P<0.001;χ^(2)=621.440,P<0.001).The crude mortality rates of Alzheimer's disease showed increasing trends in the eastern,central and western regions of China(AAPC=2.59%,P<0.001;AAPC=6.11%,P=0.001;AAPC=6.66%,P<0.001),and the crude mortality rate and standardized mortality rate were higher in the eastern region than in the western region and in the western region than in the central region(χ^(2)=10,766.460,P<0.001;χ^(2)=34720.920,P<0.001).Conclusion The mortality rate of Alzheimer's disease in residents aged≥40 years showed an increasing trend year by year in China from 2013 to 2021.There were gender,age,urban-rural status and region specific differences in Alzheimer's disease mortality.Women,the elderly,and residents in rural area and eastern region are high-risk groups,to whom priority attention should be paid.