文献类型：期刊文献

英文题名：Effects of long-term exposure to PM_2.5 and chemical constituents on blood lipids in an essential hypertensive population: A multi-city study in China

作者：Lei, Ruoyi[1];Wang, Zengwu[2];Wang, Xin[2];Tian, Hezhong[3];Wang, Bo[1];Xue, Baode[1];Xiao, Ya[4];Hu, Jihong[5];Zhang, Kai[6];Luo, Bin[1]

第一作者：Lei, Ruoyi

通信作者：Luo, B[1];Hu, JH[2];Zhang, K[3]

机构：[1]Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[2]Peking Union Med Coll & Chinese Acad Med Sci, Fuwai Hosp, Div Prevent & Community Hlth, Natl Ctr Cardiovasc Dis, Beijing 100037, Peoples R China;[3]Beijing Normal Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Cont, Beijing 100875, Peoples R China;[4]Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[6]SUNY Albany, Sch Publ Hlth, Dept Environm Hlth Sci, Rensselaer, NY 12144 USA

第一机构：Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), SUNY Albany, Sch Publ Hlth, Dept Environm Hlth Sci, Rensselaer, NY 12144 USA.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2022

卷号：242

外文期刊名：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000829845100004)】；

基金：This study was supported by the Chinese National Special Fund for Health Scientific Research in Public Welfare (200902001) , the Gansu Province Young Doctoral Fund Project (2021QB-005) , the National Natural Science Foundation of China (81872578) , and the Fundamental Research Funds for the Central Universities, Lanzhou University, China (lzujbky-2021-ey07) . We gratefully acknowledge all of the participants that contributed to this study. We wish to express our gratitude to Kai Zhang and Hezhong Tian for help in providing us access to the exposure data, and Wang Zengwu, Wang Xin and Jihong Hu for help in providing us access to the essential hypertensive population data.

语种：英文

外文关键词：Particulate matter; Chemical constituents; Lipids; Essential hypertension

摘要：Previous studies on the effects of fine particulate matter (PM2.5) and chemical constituents on lipid disorder among hypertension populations, particularly in China, are very limited. We aimed to examine the effects of long-term exposure to PM2.5 and chemical constituents on dyslipidemias in China. Finally, we included 34,841 participants with essential hypertension from 19 regions in China during 2010-2011. Data were modeled using the generalized additive mixed model. We found that PM2.5 and chemical constituents exposure were positively associated with the increased risk of dyslipidemias and increased levels of total cholesterol (TC) and triglyceride (TG). The odds ratio for hypercholesterolemia was 1.356 [95% confidence interval (CI): 1.246, 1.477] for PM2.5, and the strongest association with PM2.5 constituents was found for nitrate. Each 10 mu g/m(3) increase in PM2.5 showed a significant increase of TC by 2.60% (95% CI: 2.03, 3.17) and TG by 2.91% (95% CI: 1.60, 4.24), respectively. Meanwhile, an interquartile range increase in nitrate, ammonium and organic matter had stronger associations with TC and TG parameters than black carbon, sulfate, and mineral dust. Our findings may contribute to a better understanding of the chronic effects of PM2.5 and chemical constituents on lipid disorder in an essential hypertensive population.