文献类型：期刊文献

英文题名：Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway

作者：Zhang, Zhen-Wen[1,2,3];Wei, Pan[4];Zhang, Gui-Jun[5];Yan, Jing-Xing[2,3];Zhang, Sai[1];Liang, Jin[1];Wang, Xiao-Li[1]

第一作者：张震文;Zhang, Zhen-Wen

通信作者：Liang, J[1];Wang, XL[1]

机构：[1]Characterist Med Ctr PAPF, Tianjin Key Lab Neurotrauma Repair, Pingjin Hosp Brain Ctr, Tianjin 300162, Peoples R China;[2]Affiliated Hosp Gansu Univ Chinese Med, Dept Encephalopathy, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[4]First Peoples Hosp Long Quan Yi Dist, Dept Neurosurg, Chengdu 610000, Sichuan, Peoples R China;[5]Sichuan Univ, West China Med Sch, West China Hosp, Dept Neurosurg, Chengdu 610041, Sichuan, Peoples R China

第一机构：Characterist Med Ctr PAPF, Tianjin Key Lab Neurotrauma Repair, Pingjin Hosp Brain Ctr, Tianjin 300162, Peoples R China

通信机构：[1]corresponding author), Characterist Med Ctr PAPF, Tianjin Key Lab Neurotrauma Repair, Pingjin Hosp Brain Ctr, Tianjin 300162, Peoples R China.

年份：2022

卷号：17

期号：1

起止页码：189

外文期刊名：OPEN LIFE SCIENCES

收录：;Scopus(收录号：2-s2.0-85127601592);WOS:【SCI-EXPANDED(收录号:WOS:000770548400002)】；

基金：This work was supported by the National Nature Scientific Fund of China (81271392).

语种：英文

外文关键词：exosomes; human umbilical cord mesenchymal stem cells; neurological recovery; NF-kappa B; traumatic brain injury

摘要：Traumatic brain injury (TBI) is a predominant cause of death and permanent disability globally. In recent years, much emphasis has been laid on treatments for TBI. Increasing evidence suggests that human umbilical cord mesenchymal stem cells (HUCMSCs) can improve neurological repair after TBI. However, the clinical use of HUCMSCs transplantation in TBI has been limited by immunological rejection, ethical issues, and the risk of tumorigenicity. Many studies have shown that HUCMSCs-derived exosomes may be an alternative approach for HUCMSCs transplantation. We hypothesized that exosomes derived from HUCMSCs could inhibit apoptosis after TBI, reduce neuroinflammation, and promote neurogenesis. A rat model of TBI was established to investigate the efficiency of neurological recovery with exosome therapy. We found that exosomes derived from HUCMSCs significantly ameliorated sensorimotor function and spatial learning in rats after TBI. Moreover, HUCMSCs-derived exosomes significantly reduced proinflammatory cytokine expression by suppressing the NF-kappa B signaling pathway. Furthermore, we found that HUCMSC-derived exosomes inhibited neuronal apoptosis, reduced inflammation, and promoted neuron regeneration in the injured cortex of rats after TBI. These results indicate that HUCMSCs-derived exosomes may be a promising therapeutic strategy for TBI.