文献类型：期刊文献

中文题名：基于自噬探讨中医药抗肝纤维化的研究进展

英文题名：Traditional Chinese Medicine Against Liver Fibrosis Based on Autophagy:A Review

作者：田萌媛[1];张铭[1];赵哲[1];靳玉秋[1];陈光顺[1]

第一作者：田萌媛

机构：[1]甘肃中医药大学,兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：29

期号：21

起止页码：255

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：兰州市科学技术局项目(2022-2D-134);甘肃省优秀研究生“创新之星”基金项目(2023CXZX-744)。

语种：中文

中文关键词：中医药;肝纤维化;自噬;信号通路;研究进展

外文关键词：traditional Chinese medicine;hepatic fibrosis;autophagy;signaling pathway;research progress

摘要：肝纤维化(HF)是各种慢性肝损伤导致的普遍性疾病,严重影响人类健康。HF起病隐秘,症状不显,病变后期可发展为肝硬化甚至肝细胞癌。HF病理机制十分复杂,主要表现为细胞外基质(ECM)的过度堆积。自噬是一种溶酶体介导的降解系统,用于循环利用细胞内容物,清除聚集的蛋白质、受损的细胞器和入侵的病原体(如病毒和细菌),以维持正常的细胞功能和动态平衡。自噬可以通过调节多种信号通路和因子,如哺乳动物雷帕霉素靶蛋白(mTOR)、单磷酸腺苷活化蛋白激酶(AMPK)、转化生长因子-β(TGF-β)等,减少肝星状细胞(HSC)的活化及肝细胞的坏死凋亡,从而减轻ECM的沉积及延缓HF的进程。且大量研究表明中医药能够有效治疗肝纤维化,且作用机制可能与自噬相关。该文通过汇总分析近年来国内外文献,从自噬的作用机制及相关信号因子、通路,以及中医药通过调控自噬防治HF方面进行综述,以期为防治HF中药的开发与临床合理用药研究提供参考。
Hepatic fibrosis(HF)is a widespread disease caused by various forms of chronic liver injury,significantly impacting human health.HF often has an insidious onset with inconspicuous symptoms,but in its advanced stages,it can progress to cirrhosis or even hepatocellular carcinoma.The pathogenic mechanisms of HF are highly complex,primarily characterized by excessive extracellular matrix(ECM)deposition.Autophagy is a lysosome-mediated degradation system employed by cells to recycle cellular contents,eliminate aggregated proteins,damaged organelles,and invading pathogens(such as viruses and bacteria)to maintain normal cellular function and dynamic balance.Autophagy can regulate various signaling pathways and factors,including mammalian target of rapamycin(mTOR),adenosine monophosphate-activated protein kinase(AMPK),and transforming growth factor-β(TGF-β),to reduce the activation of hepatic stellate cells(HSCs)and hepatocyte necrosis and apoptosis,thereby mitigating ECM deposition and slowing the progression of HF.Numerous studies also suggest that traditional Chinese medicine(TCM)can effectively treat HF,and its mechanism of action may be related to autophagy.This article provides a review by summarizing recent literature in China and abroad on the mechanisms of autophagy,related signaling factors and pathways,as well as the role of TCM in regulating autophagy for the prevention and treatment of HF,aiming to offer insights and references for the development of TCM in the prevention and clinical rational medication in the treatment of HF.