文献类型：期刊文献

中文题名：金匮肾气丸对2型糖尿病肾病大鼠IGF-1及ET的影响

英文题名：Effects of "Jinkui Shenqi Pill" on insulin-like growth factor-Ⅰ and endothelin in rats of type 2 diabetic nephropathy

作者：金智生[1];李甜[1];陈雪[1]

第一作者：金智生

机构：[1]甘肃中医学院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2011

卷号：45

期号：11

起止页码：76

中文期刊名：上海中医药杂志

外文期刊名：Shanghai Journal of Traditional Chinese Medicine

收录：CSTPCD

基金：甘肃省教育厅科研项目(0606-06)

语种：中文

中文关键词：金匮肾气丸;糖尿病肾病;尿白蛋白排泄率;胰岛素样生长因子-1;血浆内皮素

外文关键词：＂ Jinkui Shenqi Pill＂ ; diabetic nephropathy ; urinary atbumin excretion rate ; Insulin-like growth factor-I ; endothelin

摘要：目的探讨金匮肾气丸对2型糖尿病肾病大鼠胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)及血浆内皮素(endo-thelin,ET)的影响。方法抽取8只大鼠为空白组,其余均制备糖尿病肾病模型。选择造模成功的大鼠40只,随机分为模型组、罗格列酮组、金匮肾气大、中、小剂量组;各组给予相应干预措施共5周,检测空腹血糖(FBG)、尿白蛋白排泄率(UAER)、IGF-1及ET。结果各组给药后FBG较给药前明显降低,差异有统计学意义(P<0.05,P<0.01);各药物组FBG较模型组明显降低,差异有统计学意义(P<0.05,P<0.01);金匮肾气大剂量组与罗格列酮组血糖降低程度相当(P>0.05),金匮肾气中、小剂量组较金匮肾气大剂量组与罗格列酮组血糖差异有统计学意义(P<0.01)。与模型组比较,各药物组UAER降低,差异有统计学意义(P<0.05,P<0.01);IGF-1升高,ET降低,差异有统计学意义(P<0.01)。金匮肾气各剂量组与罗格列酮组比较,IGF-1差异无统计学意义,ET除金匮肾气小剂量组外(P<0.05),金匮肾气大、中剂量组差异无统计学意义(P>0.05)。与金匮肾气大剂量组比较,中、小剂量组UAER差异有统计学意义(P<0.05,P<0.01);与金匮肾气小剂量组比较,大、中剂量组ET差异有统计学意义(P<0.01)。结论金匮肾气丸可以降低2型糖尿病肾病大鼠FBG、UAER、ET,升高IGF-1,从而起到防治糖尿病肾病的作用。
Objective To observe the effects of ＂Jinkui Shenqi Pill＂ on IGF-I and ET in rats of type 2 diabetic nephropathy. Methods Eight rats were selected randomly in blank group. Another 40 rats were created into the diabetic nephropathy rats, and then divided into five groups： model group, rosiglitazonc group, Jinkui shenqi groups（large, medium and small dose）. Each group was treated for five weeks. The fasting blood glucose（ FBG）, urinary albumin excretion rate （ UAER）, IGF-1 and ET were detected. Results The levels of FBG was decreased significantly alter treatment（ P 〈 0.05, P 〈 0.01 ） ; compared with the model group, the bluud glucose in treatment groups was decreased significantly（ P 〈0.05, P 〈0.01 ）. Compared with the model group, the UAER was decreased significantly（ P 〈 0.05, P 〈 0.01 ） , IGF-I was increased, ET was decreased significantly（P 〈 0.01 ）. Compared Jinkui shenqi groups with rosiglitazone group, IGF-I was insignificant. Expect ET in low dose Jinkui shenqi group（ P 〈 0.05 ）, the large dose group and medium dose group were insignificant. Conclusion ＂Jinkui Shenqi Pill＂ has positive effects to prevent and treat DN by lowering the levels of blood glucose, UAER and ET, and increasing the levels of IGF-I.