文献类型：期刊文献

中文题名：固本益肾胶囊对肾缺血再灌注模型大鼠的保护作用

英文题名：Protective effect of Guben Yishen Capsule on renal ischemia reperfusion injury in rats

作者：马骏[1];傅毓[1];刘兴国[1];贾小翠[2];刘艳春[3]

第一作者：马骏

机构：[1]甘肃中医学院,甘肃兰州730000;[2]甘肃省庆阳市人民医院,甘肃庆阳745000;[3]甘肃省庆阳市妇幼保健院,甘肃庆阳745000

第一机构：甘肃中医药大学

年份：2011

卷号：33

期号：5

起止页码：767

中文期刊名：中成药

外文期刊名：Chinese Traditional Patent Medicine

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：甘肃省庆阳市科技局项目(0902NKCM065)

语种：中文

中文关键词：固本益肾胶囊;肾缺血再灌注;保护作用

外文关键词：Guben Yishen Capsule; renal ischemia reperfusion injury; protective effects

摘要：目的研究固本益肾胶囊(人参、三七、紫河车、水蛭、车前子等)对肾缺血再灌注模型大鼠的保护作用,并探讨其作用机制。方法 50只大鼠随机分成5组(每组10只)采用夹闭左右肾动静脉1h,再灌注24h的方法复制肾缺血再灌注模型。术后24h股动脉取血,检测各组大鼠血清超氧化物歧化酶(SOD)、丙二醛(MDA)、肌酐(Scr)和尿素氮(BUN)的含量及肾组织病理学改变。结果固本益肾胶囊能显著升高由缺血再灌注引起的大鼠血清SOD水平下降,减少MDA、Scr、BUN的生成,肾组织病理改变减轻。结论固本益肾胶囊对肾脏缺血再灌注具有保护作用,这种保护作用可能与其抗自由基损伤、减轻脂质过氧化反应、减少Scr和BUN水平有关。
AIM To study the protective effect of Guben Yishen Capsule（GB-C） on renal ischemia reperfusion injury in rats,and discuss its mechanism.METHODS Fifty rats were randomly assigned to five groups（10 rats each group）.All of groups（except for normal group） were made up by clamping bilateral renal artery for 60 min and reperfusion for 24 h into a model of renal ischemia reperfusion injury,and then the blood samples of femoral artery were collected and the level of SOD,MDA,Scr and BUN in blood serum was measured,and the change of renal histomorphology was observed.RESULTS GB-C significantly enhanced the level of SOD,reduced the concentration of MDA,Scr,and BUN in kidney after ischemia reperfusion.CONCLUSION Guben Yishen Capsule may have medicinal properties of anti-oxidative and reduce the level of MDA,Scr,BUN against renal ischemia reperfusion injuries in rats,possibly by alleviating the damages caused by free radicals and lipid peroxidation.