文献类型：期刊文献

中文题名：基于流变学指标的后交联祖师麻凝胶贴膏剂混合工艺研究

英文题名：Study on mixing technology of post-crosslinking Daphnes Giraldii Cortex gel plaster based on rheological indexes

作者：万玲娟[1];李真真[1];魏舒畅[1];刘晓霞[1];王继龙[1];石盘棋[1];孙晓燕[1]

第一作者：万玲娟

机构：[1]甘肃中医药大学甘肃省中药制药工艺工程研究中心,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2020

卷号：51

期号：12

起止页码：3187

中文期刊名：中草药

外文期刊名：Chinese Traditional and Herbal Drugs

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：甘肃省基础研究创新群体项目(1506RJIA034)。

语种：中文

中文关键词：祖师麻;凝胶贴膏;混合工艺;流变学特性;黏弹性;耐温耐剪切性;抗变形能力;稳定性;弹性模量;黏性模量;屈服应力;蠕变柔量;损耗系数

外文关键词：Daphnes Giraldii Cortex;gel plaster;mixing technology;rheological properties;viscoelasticity;temperature and shear resistance;deformation resistance;stabilization;elastic modulus;viscous modulus;yield stress;creep compliance;loss coefficient

摘要：目的以流变学参数弹性模量(G′)、黏性模量(G″)、屈服应力(τ0)、蠕变柔量[J(t)]及损耗系数(tanδ)作为评价指标,优化祖师麻凝胶贴膏剂(Daphnes Giraldii Cortex gel plaster,DGCGP)混合工艺。方法采用正交设计,选用L9(34)正交试验表,以物料混合时的温度、转速以及混合时间为考察因素,以混合后含药胶料的各项流变学参数为评价指标,筛选出DGCGP最佳的混合工艺,并预测适合的涂布条件。结果优选的DGCGP混合工艺为混合温度70℃,转速10 r/min,时间2 h,在此条件下,混合胶料的黏弹性、耐温耐剪切性、抗变形能力以及稳定性均良好。结论采用优化工艺条件制备的DGCGP外观良好,且质地柔软,黏弹性好,质量较佳。
objective To optimize the mixing technology of Daphnes Giraldii Cortex gel plaster(DGCGP)by using rheological parameters elastic modulus(G′),viscous modulus(G″),yield stress(τ0),creep compliance[J(t)]and loss coefficient(tanδ)as evaluation indexes.Methods Using orthogonal design,L9(34)orthogonal design was used to screen out the best mixing technology of DGCGP and predict the suitable coating conditions by taking the temperature,rotating speed and mixing time of the mixed materials as influencing factors and the rheological parameters of the medicated compound as evaluating indexes.Results The optimum DGCGP mixing process was as following:70℃at 10 r/min for 2 h.Under this condition,the viscoelasticity,temperature and shear resistance,deformation resistance and stability of the mixture were all good.Conclusion DGCGP prepared by this optimized process had good appearance,soft texture,good adhesion with skin,good viscoelasticity and better quality.