文献类型：期刊文献

中文题名：MicroRNA通过肠道菌群对绝经后骨质疏松症影响的机制探讨

英文题名：The regulatory mechanism of microRNA regulating intestinal flora in postmenopausal osteoporosis

作者：范中正[1];董万涛[2];刘保健[2];宋敏[1];赵天宇[1]

第一作者：范中正

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院

第一机构：甘肃中医药大学

年份：2021

卷号：33

期号：9

起止页码：1100

中文期刊名：中国微生态学杂志

外文期刊名：Chinese Journal of Microecology

收录：CSTPCD;;CSCD:【CSCD_E2021_2022】；

基金：国家自然科学基金(81960878);甘肃省自然科学基金(1506RJZA048);甘肃省创新基地和人才计划—自然科学基金项目(17JR5RA056);甘肃省中医药防治慢性疾病重点实验室开放基金项目(GSMBKY2015-07);甘肃省中医药管理局科研课题项目(GZK-2016-17)。

语种：中文

中文关键词：MicroRNA;肠道菌群;绝经后骨质疏松症;骨代谢

外文关键词：MicroRNA;Intestinal flora;Postmenopausal osteoporosis;Bone metabolism

摘要：胃肠道是营养和矿物质高效吸收的重要部位。研究显示胃肠道微生物群通过肠-骨轴对骨质量具有调节作用,其作用机制十分复杂,主要通过矿物质吸收、激素控制和免疫调节来实现。中药可以调节肠道菌群,起到治疗绝经后骨质疏松症的作用。近期研究发现,microRNA通过调节肠道微生物基因,改变肠道微生物的生理功能,从而调节骨代谢,影响绝经后骨质疏松症的发生与发展。本文就microRNA调节肠道菌群的研究现状作一综述,探讨绝经后骨质疏松症的调节机制,为绝经后骨质疏松症的肠道微生态研究提供一定的理论依据。
Gastrointestinal tract is an important part of gastrointestinal tract for efficient absorption of nutrients and minerals. Research showed that gastrointestinal tract microbiota can regulate bone quality through gut-bone axis.The mechanism of act is very complex, which is mainly achieved through mineral absorption, hormone control and immune regulation. Traditional Chinese medicine can adjust the intestinal flora and play a role in the treatment of postmenopausal osteoporosis.Recent studies have found that microRNA changes the physiological functions of intestinal microorganisms by regulating intestinal microbial genes, thereby regulating bone metabolism and affecting the occurrence and development of postmenopausal osteoporosis.In this paper, the current status of research on the regulatory effect of microRNA on intestinal flora was reviewed in detail, and the mechanism of the regulation on postmenopausal osteoporosis was discussed, so as to provide theoretical basis for the research on intestinal microecology in postmenopausal osteoporosis.