文献类型：期刊文献

英文题名：A clinical study of the CALLY index and HALP score for evaluating response to FOLFOX in colorectal cancer with lung metastases

作者：Wang, Li[1];Yan, Xia[1];Luan, Jing[2];Yang, Xiaoran[1];Wang, Chenghua[3];Li, Ting[3];Wen, Hongxu[4]

第一作者：王力;王莉;王丽

通信作者：Wen, HX[1]

机构：[1]Gansu Univ Chinese Med, Peoples Hosp Lanzhou City 1, Clin Med Coll 2, Dept Geratol, 1 Wujia Yuan West St, Lanzhou 730050, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Peoples Hosp Lanzhou City 1, Clin Med Coll 2, Dept Crit Care Med, 1 Wujia Yuan West St, Lanzhou 730050, Gansu, Peoples R China;[3]2 Peoples Hosp Lanzhou, Dept Gastroenterol, 388 Jingyuan Rd, Lanzhou 730046, Gansu, Peoples R China;[4]Taizhou Univ, Taizhou Cent Hosp, Dept Gastroenterol, Affiliated Hosp, 999 Donghai Ave, Taizhou 318000, Zhejiang, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Taizhou Univ, Taizhou Cent Hosp, Dept Gastroenterol, Affiliated Hosp, 999 Donghai Ave, Taizhou 318000, Zhejiang, Peoples R China.

年份：2026

卷号：18

期号：5

起止页码：4133

外文期刊名：AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001786759700004)】；

基金：This work is supported by Natural Science Foundation of Gansu Province (24JRRA768) .

语种：英文

外文关键词：CALLY index; HALP score; colorectal cancer; lung metastasis; FOLFOX

摘要：Objectives: To evaluate the predictive value of the C-reactive protein-albumin-lymphocyte (CALLY) index and the hemoglobin-albumin-lymphocyte-platelet (HALP) score for chemotherapy response and survival outcomes in colorectal cancer (CRC) patients with pulmonary metastases treated with FOLFOX chemotherapy. Methods: This retrospective study included CRC patients with lung metastases who received first-line FOLFOX-based chemotherapy. Receiver operating characteristic (ROC) curve analysis was used to determine optimal cutoff values for CALLY and HALP in predicting objective response. Logistic regression analyses were performed to identify factors associated with objective response. Progression-free survival (PFS) and overall survival (OS) were analyzed using the Kaplan-Meier method and Cox proportional hazards models. Combined risk stratification based on CALLY and HALP was further evaluated. Results: Both CALLY and HALP scores were significantly higher in patients achieving objective response than those in non-responders. In multivariable logistic regression, CALLY and HALP were independent protective factors for objective response. Survival analyses demonstrated that low CALLY and low HALP were associated with significantly shorter PFS and OS. In multivariable Cox analyses, HALP remained an independent predictor for both PFS and OS, whereas CALLY was independently associated with PFS and showed a borderline association with OS. Combined stratification based on CALLY and HALP further improved prognostic discrimination. Time-dependent ROC analysis showed that the combined score achieved the highest predictive accuracy at 24 months. Conclusions: CALLY and HALP scores are effective predictors of chemotherapy response and survival in CRC patients with pulmonary metastases receiving FOLFOX. Their combined application enhances risk stratification and may assist in individualized treatment decision-making.