文献类型：期刊文献

中文题名：当归对自发性高血压大鼠脑组织Tnfaip8l2、Ahsg及Tlr3基因表达的影响

英文题名：The Effect of Angelica on Expression of Tnfaip8l2,Ahsg and TLR3 Gene in Brain Tissue of Spontaneously Hypertensive Rats

作者：伊琳[1];赵昕[2];李屹[1]

第一作者：伊琳

机构：[1]甘肃中医学院中西医结合系;[2]兰州大学基础医学院遗传学研究所,甘肃省兰州市730000

第一机构：甘肃中医药大学中西医结合学院

年份：2013

卷号：21

期号：10

起止页码：891

中文期刊名：中国动脉硬化杂志

外文期刊名：Chinese Journal of Arteriosclerosis

收录：CSTPCD;;北大核心:【北大核心2011】；CSCD:【CSCD_E2013_2014】；

语种：中文

中文关键词：当归;基因表达谱;肿瘤坏死因子α诱导蛋白8样蛋白;α2-HS糖蛋白;Toll样受体3

外文关键词：Angelica; Gene Expressive Profile ; Tnfaip812 ; Ahsg; Tlr3

摘要：目的探讨当归对自发性高血压(SHR)大鼠脑组织肿瘤坏死因子α诱导蛋白8样蛋白(Tnfaip8l2)、α2-HS糖蛋白(Ahsg)及Toll样受体3(Tlr3)基因表达谱的影响。方法将SHR大鼠分为当归组、模型组,并将同周龄的Wistar大鼠作为对照组。测定用药前后各组尾动脉收缩压;分组灌胃给药4周后,取大鼠脑组织,提取RNA进行表达谱的测定。结果当归可降低SHR大鼠的血压水平;同时基因表达谱分析显示当归可导致Tnfaip8l2、Ahsg及TLR3基因表达上调,且为差异表达上调基因,而这三个基因均为动脉粥样硬化抑制因子。结论当归具有一定的降压作用,并对SHR脑组织基因表达谱产生影响,通过抑制动脉粥样硬化的发生发挥作用。
Aim To clarify the effects of Angelica on Tnfaip8l2,Ahsg and Tlr3 gene of brain in spontaneously hypertensive rats （SHR）. Methods The SHR were divided into Angelica group and model group,week-old Wistar rats was act as control group. Systolic blood pressure was measured in different groups before and after treatment,after 4 weeks,RNA from brain of mice was extracted and gene expressive profile was measured. Results Angelica can reduce blood pressure levels in SHR. Compared with the model group,Tnfaip8l2,Ahsg and Tlr3 gene in Angelica group were up-regulated in gene expression profile which biology process was all related to inhibition of atherosclerosis. Conclusion Angelica has some function of antihypertensive and can regulate the gene expression profile of brain in SHR. Angelica produce marked effect mainly through inhibiting atherosclerosis.