文献类型：期刊文献

中文题名：中药抗乳腺增生作用机制研究进展

英文题名：Progress on mechanism research of traditional Chinese medicine and compound prescription on mammary gland hyperplasia

作者：连小龙[1];韩涛[1]

第一作者：连小龙

机构：[1]甘肃中医药大学药学院,甘肃兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2017

卷号：36

期号：3

起止页码：80

中文期刊名：中兽医医药杂志

外文期刊名：Journal of Traditional Chinese Veterinary Medicine

基金：国家自然科学基金项目(编号:81560722)

语种：中文

中文关键词：乳腺增生;中药;作用机制

外文关键词：hyperplasia of mammary glands; traditional Chinese medicine; mechanism of action

摘要：目的:探讨中药及复方抗乳腺增生的作用机制,为乳腺增生进一步研究提供理论依据。方法:以"乳腺增生"为关键词,在"知网"、"万方"、"维普"数据库检索,选择相关文献。结果:中药通过调节激素和受体水平、抗新生血管生成、抗氧化、改善血液黏稠度、调节免疫功能、诱导细胞凋亡、调控微量元素来达到治疗乳腺增生的作用。结论:乳腺增生实验研究中,抗乳腺增生作用机制研究缺少系统性,只注重单个方面的研究。因此,今后应当围绕Kisspeptin/GPR54系统以及下丘脑-垂体-卵巢轴来研究抗乳腺增生作用机制。
Objective： To explore the mechanism of traditional Chinese medicine and compound anti hyperplasia of mammary glands, and provide theoretical basis for further study of mammary gland hyperplasia. Methods： Breast hyperplasia was used as key words in CNKI, WANFANG and VIP database, then the relevant literature were selected. Results： Traditional Chinese medicine and compound could achieve the treatment of breast hyperplasia by regulating hormones and receptor, antiangiogenesis, antioxidant, improving blood viscosity, regulating immune function, inducing cell apoptosis and regulating trace elements level. Conclusion： There is no systematic study on the mechanism of mammary gland hyperplasia in the experimental study, and it is focused on one aspect of the study. Therefore, in the future research, the study should be based on the Kisspeptin/GPR54 system and the hypothalamic-pituitary-ovarian axis.