文献类型：期刊文献

中文题名：中药单体介导相关信号通路治疗椎间盘退行性变研究现状

英文题名：Research status of traditional Chinese medicine monomer mediating related signaling pathways in treatment of intervertebral disc degeneration

作者：杨云云[1];陈祁青[2];赵继荣[1];朱宝[2];马东[1];黄军凯[1];安德浩[1];邹继鹏[1];刘伟航[3]

第一作者：杨云云

机构：[1]甘肃中医药大学,甘肃省兰州市730030;[2]甘肃省中医院,甘肃省兰州市730000;[3]易县中医院,河北省易县074200

第一机构：甘肃中医药大学

年份：2024

卷号：28

期号：18

起止页码：2918

中文期刊名：中国组织工程研究

外文期刊名：Chinese Journal of Tissue Engineering Research

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；

基金：国家自然科学基金项目(81760877),项目负责人:赵继荣;甘肃省科技重大项目(21ZD4FA009),项目负责人:赵继荣;甘肃省创新基地和人才计划-自然科学基金(17JR5RA051),项目负责人:陈祁青;甘肃省中医院博士科研启动基金项目(2018-01),项目负责人:陈祁青;国家中医药管理局项目(国中医药科技中药便函【2023】24号),项目负责人:陈祁青。

语种：中文

中文关键词：椎间盘退行性变;髓核细胞;细胞外基质;中药;信号通路;内源性修复;综述

外文关键词：intervertebral disc degeneration;nucleus pulposus cell;extracellular matrix;Chinese herbal medicine;signaling pathway;endogenous repair;review

摘要：背景:椎间盘退行性变是由一系列复杂的分子机制引起的椎间盘衰老、损伤,最终导致严重临床症状的一种病理性变化。中药具有价格低廉、无成瘾性、作用靶点多、毒副作用少、易被患者接受的特点,在椎间盘退行性变治疗中具有独特的优势。目的:综述中药单体干预相关信号通路治疗椎间盘退行性变的最新研究成果,阐析中药单体对椎间盘退行性变的作用机制,为未来的基础研究和临床治疗提供新的途径和理论依据。方法:第一作者通过中国知网、PubMed、维普、万方数据库查阅2018年1月至2023年2月国内外相关文献,检索词为“椎间盘,信号通路”“intervertebral disc,signal”。通过初步筛查文献标题及摘要,排除不符合的文献,最终选取72篇文献进行综述分析。结果与结论:中药单体可以调节多种经典信号通路,如Wnt/β-catenin、PI3K/Akt、mTOR、NF-κB、MAPK等,通过调节氧化应激调整细胞内促/抗凋亡蛋白的表达,刺激细胞自噬功能,减轻细胞炎性因子刺激,提高细胞外基质标志物的表达,减少基质降解酶的产成,维持细胞外基质的合成稳定,并诱导髓核间充质干细胞向髓核细胞分化,促进细胞内源性修复与重建,控制髓核细胞凋亡和衰老,提高髓核细胞的活性,从而改善椎间盘内部微环境,维持椎间盘正常生理功能,延缓椎间盘退行性变。
BACKGROUND:Intervertebral disk degeneration is a pathological change caused by a series of complex molecular mechanisms that result in the aging and damage of intervertebral discs,ultimately leading to severe clinical symptoms.Traditional Chinese medicine has unique advantages in the treatment of intervertebral disk degeneration due to its low cost,non-addictive nature,multi-target effects,minimally toxic and side effects,and high patient acceptance.OBJECTIVE:To review the latest research results of traditional Chinese medicine monomer intervention-related signaling pathways in the treatment of intervertebral disk degeneration,describe and analyze the action mechanism of traditional Chinese medicine monomer on intervertebral disk degeneration,and provide a new approach and theoretical basis for future basic research and clinical treatment.METHODS:The first author searched for relevant literature from January 2018 to February 2023 in CNKI,PubMed,VIP,and WanFang using the search terms“intervertebral disc,signal pathway”.The articles that did not meet the criteria were excluded after preliminary screening of the titles and abstracts.Finally,72 articles were selected for review and analysis.RESULTS AND CONCLUSION:Traditional Chinese medicine monomers can regulate multiple classical signaling pathways such as Wnt/β-catenin,PI3K/Akt,mTOR,NF-κB,and MAPK.They achieve this by regulating oxidative stress,adjusting the expression of pro/anti-apoptotic proteins in cells,stimulating cellular autophagy function,reducing stimulation of cell inflammatory factors,increasing the expression of extracellular matrix markers,reducing the production of matrix-degrading enzymes,maintaining the synthesis and stability of extracellular matrix,inducing differentiation of mesenchymal stem cells in the nucleus pulposus into nucleus pulposus cells,promoting endogenous repair and reconstruction,controlling apoptosis and aging of nucleus pulposus cells,and increasing the activity of nucleus pulposus cells.These actions improve the microenvironment within the intervertebral disc,maintain the normal physiological function of the intervertebral disc,and delay intervertebral disc degeneration.