文献类型：期刊文献

中文题名：中医药调控微RNA干预心肌缺血再灌注损伤研究进展

英文题名：Research Progress of miRNA Modulation by Traditional Chinese Medicine to Intervene Myocardial Ischemia Reperfusion Injury

作者：李嘉玮[1];张玲娜[1];路玉媛[1];沈路凡[1];寇雨顺[1];兰雪艳[1];滕政杰[3];伊琳[2]

第一作者：李嘉玮

机构：[1]甘肃中医药大学中西医结合学院,兰州730000;[2]甘肃中医药大学甘肃省中医药防治慢性疾病重点实验室,兰州730000;[3]甘肃中医药大学附属医院心血管一科,兰州730000

第一机构：甘肃中医药大学中西医结合学院

年份：2026

卷号：43

期号：7

起止页码：1233

中文期刊名：中国现代应用药学

外文期刊名：Chinese Journal of Modern Applied Pharmacy

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金项目(82160842);甘肃省联合科研基金一般项目(23JRRA1521);甘肃省中医药科研项目(GZKP-2022-40);甘肃中医药大学研究生“创新创业基金”项目(2025CXCY-012)。

语种：中文

中文关键词：心肌缺血再灌注损伤;微RNA;中医药;分子机制

外文关键词：myocardial ischemia reperfusion injury;microRNA;traditional Chinese medicine;molecular mechanism

摘要：心肌缺血再灌注损伤(myocardial ischemia reperfusion injury,MIRI)是心肌梗死后血流恢复再灌注时所诱发的心肌损害加剧现象,其病理过程涉及多种复杂的细胞及分子机制,已成为影响心血管疾病患者预后、转归的严重并发症之一,目前临床尚缺乏有效的防治措施。微RNA(microRNA,miRNA)能够靶向调控细胞分化、凋亡、自噬、氧化应激及能量代谢障碍等过程,被视为多种疾病的生物标志物。近年来,越来越多miRNA被发现对MIRI的发生发展具有关键调控作用。中医药治疗MIRI具有多靶点、多层次的优势。本文综述了miRNA在MIRI中的相关调控通路及效应,并分析了中药单体、复方及中成药通过靶向miRNA干预MIRI的治疗效果及分子机制,以期为推动中医药治疗MIRI的基础研究转化及拓展临床思路提供参考。
Myocardial ischemia reperfusion injury(MIRI)is further myocardial damage induced by blood flow restoration following myocardial infarction,which involves a variety of complex cellular and molecular mechanisms,and has become one of the serious complications affecting the prognosis and regression of patients with cardiovascular diseases.Currently,effective preventive and therapeutic measures are still lacking in clinical practice.MicroRNA(miRNA)can target and regulate processes such as cell differentiation,apoptosis,autophagy,oxidative stress,and energy metabolism disorders,and is regarded as biomarkers for many diseases.In recent years,an increasing number of miRNAs have been found to play a key regulatory role in the occurrence and development of MIRI.Traditional Chinese medicine has the advantages of multi-target and multi-level effects in treating MIRI.This article reviews the relevant regulatory pathways and effects of miRNAs in MIRI,and analyzed the therapeutic efficacy and molecular mechanisms of traditional Chinese medicine monomers,compound prescription and Chinese patent medicines on MIRI by targeting miRNAs,aiming to provide references for translating basic research on traditional Chinese medicine treatment of MIRI into clinical practice and expanding clinical ideas.