文献类型：期刊文献

英文题名：Research progress on the role of lncRNA-miRNA networks in regulating adipogenic and osteogenic differentiation of bone marrow mesenchymal stem cells in osteoporosis

作者：An, Fangyu[1];Wang, Xiaxia[2];Wang, Chunmei[3];Liu, Ying[3];Sun, Bai[2];Zhang, Jie[3];Gao, Peng[3];Yan, Chunlu[2]

第一作者：安方玉

通信作者：Yan, CL[1]

机构：[1]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Trad Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Trad Chinese & Western Med, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：14

外文期刊名：FRONTIERS IN ENDOCRINOLOGY

收录：;Scopus(收录号：2-s2.0-85169311940);WOS:【SCI-EXPANDED(收录号:WOS:001055173100001)】；

基金：This study was supported by the National Natural Science Foundation of China (82060872), the Natural Science Program in Gansu Province (21JR11RA138), the Project in Science and Technique Plans of Lanzhou City(2022-3-22), and the Young Doctor Fund Program of Colleges and Universities, Gansu Province (2022QB-091).

语种：英文

外文关键词：osteoporosis; bone marrow mesenchymal stem cells; adipogenic-osteogenic differentiation; lncRNA-miRNA network; crosstalk regulation

摘要：Osteoporosis (OP) is characterized by a decrease in osteoblasts and an increase in adipocytes in the bone marrow compartment, alongside abnormal bone/fat differentiation, which ultimately results in imbalanced bone homeostasis. Bone marrow mesenchymal stem cells (BMSCs) can differentiate into osteoblasts and adipocytes to maintain bone homeostasis. Several studies have shown that lncRNAs are competitive endogenous RNAs that form a lncRNA-miRNA network by targeting miRNA for the regulation of bone/fat differentiation in BMSCs; this mechanism is closely related to the corresponding treatment of OP and is important in the development of novel OP-targeted therapies. However, by reviewing the current literature, it became clear that there are limited summaries discussing the effects of the lncRNA-miRNA network on osteogenic/adipogenic differentiation in BMSCs. Therefore, this article provides a review of the current literature to explore the impact of the lncRNA-miRNA network on the osteogenic/adipogenic differentiation of BMSCs, with the aim of providing a new theoretical basis for the treatment of OP.