文献类型：期刊文献

英文题名：The role of exosome lipids in central nervous system diseases

作者：Wang, Ge[1,2];Wang, Yong[3];Liu, Ningyuan[2];Liu, Mujun[1,2]

第一作者：Wang, Ge

通信作者：Liu, MJ[1];Liu, MJ[2]

机构：[1]Cent South Univ, Sch Life Sci, Dept Cell Biol, Changsha 410078, Hunan, Peoples R China;[2]Cent South Univ, Xiangya Sch Med, Changsha 410078, Hunan, Peoples R China;[3]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：Cent South Univ, Sch Life Sci, Dept Cell Biol, Changsha 410078, Hunan, Peoples R China

通信机构：[1]corresponding author), Cent South Univ, Sch Life Sci, Dept Cell Biol, Changsha 410078, Hunan, Peoples R China;[2]corresponding author), Cent South Univ, Xiangya Sch Med, Changsha 410078, Hunan, Peoples R China.

年份：2020

卷号：31

期号：7

起止页码：743

外文期刊名：REVIEWS IN THE NEUROSCIENCES

收录：;Scopus(收录号：2-s2.0-85089081716);WOS:【SCI-EXPANDED(收录号:WOS:000579352700004)】；

基金：This study is supported by research funds from Graduate Education Reform Program of Central South University (160020020) and National College Students Innovation and Entrepreneurship Training Program of Central South University (GS201910533249 and ZY20181004).

语种：英文

外文关键词：central nervous system; degenerative diseases; exosomes; lipids; sphingolipidosis

摘要：Central nervous system (CNS) diseases are common diseases that threaten human health. The CNS is highly enriched in lipids, which play important roles in maintaining normal physiological functions of the nervous system. Moreover, many CNS diseases are closely associated with abnormal lipid metabolism. Exosomes are a subtype of extracellular vesicles (EVs) secreted from multivesicular bodies (MVBs) . Through novel forms of intercellular communication, exosomes secreted by brain cells can mediate inter-neuronal signaling and play important roles in the pathogenesis of CNS diseases. Lipids are essential components of exosomes, with cholesterol and sphingolipid as representative constituents of its bilayer membrane. In the CNS, lipids are closely related to the formation and function of exosomes. Their dysregulation causes abnormalities in exosomes, which may, in turn, lead to dysfunctions in inter-neuronal communication and promote diseases. Therefore, the role of lipids in the treatment of neurological diseases through exosomes has received increasing attention. The aim of this review is to discuss the relationship between lipids and exosomes and their roles in CNS diseases.