文献类型：期刊文献

英文题名：Regulatory Mechanisms of Gut Homeostasis and Bone Metabolism Interplay in Osteoporosis

作者：Qi, Peng[1];Chen, Xin[2];Liu, Hao[1];Ma, Jilong[1];Qi, Zhonghua[1];Xie, Xingwen[1,2]

第一作者：Qi, Peng

通信作者：Xie, XW[1];Xie, XW[2]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou 730000, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2025

外文期刊名：PHENOMICS

收录：Scopus(收录号：2-s2.0-86000333824);WOS:【ESCI(收录号:WOS:001445022800001)】；

基金：The authors acknowledge the use of Biorender to create schematic representations in Figs. 1 and 2. The agreement numbers associated with this use are NQ26QZVE7J and YP26QZVIJA.

语种：英文

外文关键词：Bone metabolism; Intestinal homeostasis; Osteoporosis; Intestinal flora

摘要：Osteoporosis, a prevalent metabolic bone disorder characterized by reduced bone mass and compromised bone strength, poses a substantial socioeconomic burden worldwide due to its staggering global incidence. Individuals afflicted with osteoporosis face an elevated risk of debilitating fractures, leading to compromised quality of life, disability, and increased mortality. The gut-bone axis, the intricate bidirectional communication between the gut microbiome and skeletal system, has recently emerged as a focal area in bone health research. Accumulating evidence suggests that gut homeostasis, the delicate balance of gut microbial communities, modulates bone metabolism through diverse mechanisms, potentially driving the pathogenesis of osteoporosis. Conversely, gut dysbiosis, the disruption of this equilibrium, may directly or indirectly perturb bone homeostasis, contributing to the onset and progression of osteoporosis. Elucidating the regulatory interplay between gut homeostasis and bone metabolism in the context of osteoporosis holds promising potential for developing novel preventive and therapeutic strategies, bearing profound theoretical and clinical implications.