文献类型：期刊文献

英文题名：Effects of zinc and manganese across different pregnancy trimesters on low birth weight risk: a nested case-control study

作者：Li, Yuqing[1,2];Cao, Lei[1,2];Wang, Zifu[1];Ding, Shuyu[1];Wang, Jingyan[1];Yang, Liping[1,3];Mao, Baohong[2,4]

第一作者：Li, Yuqing

通信作者：Mao, BH[1];Mao, BH[2]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Cent Hosp, Gansu Prov Matern & Child care Hosp, Dept Med Educ, Lanzhou, Gansu, Peoples R China;[3]Gansu Prov Hosp Tradit Chinese Med, Dept Publ Hlth & Infect Management, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Sch Publ Hlth, Dept Clin Epidemiol, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Prov Cent Hosp, Gansu Prov Matern & Child care Hosp, Dept Med Educ, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Sch Publ Hlth, Dept Clin Epidemiol, Lanzhou, Gansu, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2026

外文期刊名：BRITISH JOURNAL OF NUTRITION

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001674493900001)】；

基金：The authors thank all medical staff involved in the study for recruiting the participants. The authors also thank all mothers and infants who participated in the study and all investigators who contributed to data collection.This work was supported in part by Gansu Provincial Health Commission Research Project (No.GSWSKY2024-14; GSWSKY2024-49) and the Traditional Chinese Medicine Management Project of Gansu Province (No. GZKG-2024-43).Y.L.: Writing-original draft, Visualisation, Validation, Methodology, Investigation, Formal analysis, Data curation, Conceptualisation. L.C.: Validation, Visualisation, Investigation, Formal analysis, Data curation. Z.W.: Validation, Formal analysis, Data curation. S.D.: Methodology, Investigation. J.W.: Methodology, Investigation. L.Y.: Writing-review & editing, Supervision, Project administration. B.M.: Writing-review & editing, Supervision, Resources, Methodology, Funding acquisition, Conceptualisation.The authors declare that there are no conflicts of interest.

语种：英文

外文关键词：zinc; manganese; low birth weight; nested case-control; maternal nutrition

摘要：Zn and Mn are essential nutrients for fetal growth and development. Since deficiency of maternal nutrition may lead to preventable adverse pregnancy outcomes, we aimed to examine the association of maternal dietary Zn and Mn levels with low birth weight (LBW). A nested case-control study was conducted in 605 cases and 7497 controls in Lanzhou, China. Eligible participants reported on their diet and characteristics during pregnancy. The relationship between dietary Zn and Mn intake and the risk of LBW was analysed by unconditioned logistic regression and multivariate adjusted restricted cubic spline model. The receiver operating characteristic curve was used to determine the optimal cut-off values of Zn and Mn. The dietary intake below the cut-off value was defined as the low-level group, and greater than or equal to the cut-off value was defined as the high-level group. Low dietary Zn (<505 mg/d before pregnancy and <736 mg/d during pregnancy) and Mn (<266 mg/d before pregnancy and <341 mg/d during pregnancy) intake was associated with increased risk of LBW and some subtypes. Both Zn and Mn have a nonlinear relationship with the risk of LBW (P < 0001). In addition, there was a synergistic effect of low Zn and low Mn intake on LBW risk. There were separate and interaction effects of Zn and Mn on the occurrence of LBW. An appropriate range of Zn and Mn intake may be beneficial to reduce the risk of LBW.