文献类型：期刊文献

英文题名：Harnessing RNA therapeutics: novel approaches and emerging strategies for cardiovascular disease management

作者：Wang, Dui[1];Zhao, Xiaobin[1];Zhang, Haifeng[1];Dang, Lijuan[2];Huang, Wenhui[3];Zhang, Zhengfeng[1];Song, Jinling[1]

第一作者：王丹;王端

通信作者：Song, JL[1]

机构：[1]Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Cardiovasc Rehabil, Baiyin, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Endocrinol, Baiyin, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Cardiovasc Dept, Baiyin, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Cardiovasc Rehabil, Baiyin, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：12

外文期刊名：FRONTIERS IN CARDIOVASCULAR MEDICINE

收录：;Scopus(收录号：2-s2.0-105001637770);WOS:【SCI-EXPANDED(收录号:WOS:001457605800001)】；

基金：We would like to thank the Third Affiliated Hospital of Gansu University of Chinese Medicine and the Gansu Provincial Science and Technology Program for their support and facilitation of this review.

语种：英文

外文关键词：cardiovascular diseases; RNA therapeutics; mRNA; siRNA; miRNA; RNA aptamers; RNA delivery systems

摘要：RNA therapeutics are emerging as a promising approach for cardiovascular diseases (CVDs) management, offering targeted gene regulation through modalities like mRNA, siRNA, and miRNA. In recent years, researchers have conducted a lot of research on the application of RNA therapeutics technology in the treatment of CVDs. Despite hurdles in off-target effects and immune responses, the clinical trial outcomes are encouraging. This review synthesizes the current progress in RNA therapeutics for CVDs, examining their mechanisms, advantages, and challenges in delivery and safety. We highlight the potential of personalized medicine, combination artificial intelligence (AI) and bioinformatics in advancing RNA therapeutics. The future of RNA therapeutics in CVDs is poised for significant impact, necessitating continued research and interdisciplinary collaboration to optimize these treatments and ensure patient safety and efficacy.