文献类型：期刊文献

英文题名：Expression and clinical significance of paired- related homeobox 1 and Smad2 in gastric cancer

作者：Yang, Zhong[1,3];Huang, Wan-Xia[1,3];Wang, Shang[2,3];Yao, Ji-Bin[3];Da, Mingxu[3]

第一作者：Yang, Zhong

通信作者：Da, MX[1]

机构：[1]Ningxia Med Univ, Dept Clin Med Coll, Yinchuan, Ningxia, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Dept Clin Med Coll, Lanzhou 730000, Peoples R China;[3]Gansu Prov Hosp, Dept Surg Oncol, Lanzhou 730000, Peoples R China

第一机构：Ningxia Med Univ, Dept Clin Med Coll, Yinchuan, Ningxia, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Surg Oncol, Lanzhou 730000, Peoples R China.

年份：2021

卷号：30

期号：2

起止页码：154

外文期刊名：EUROPEAN JOURNAL OF CANCER PREVENTION

收录：;Scopus(收录号：2-s2.0-85102088502);WOS:【SCI-EXPANDED(收录号:WOS:000639296200006)】；

基金：This study was funded by National Natural Science Foundation of China (Grant no. 81560391), Gansu Provincial Hospital Within-hospital Research Fund Project (Grant no. 19SYPYA-7).All authors read and approved the final manuscript.

语种：英文

外文关键词：E-cadherin; gastric cancer; Smad2; PRRX1; vimentin

摘要：Background China has a high incidence rate and low survival rate of gastric cancer. Therefore, there is a great need to further identify novel oncogenes and clinically applicable molecular targets for the diagnosis and treatment of this disease. Methods Expressions of PRRX1, Smad2, epithelial phenotype marker E-cadherin, and interstitial phenotype vimentin protein in a sample of 64 gastric carcinoma and adjacent nontumorous tissues were detected by immunohistochemistry. Their relationship and correlations with clinicopathological features were analyzed. Results The positive rates of PRRX1, Smad2, E-cadherin, and vimentin protein in primary tumors were 60.94% (39/64), 59.38% (38/64), 34.38%(22/64), and 64.06% (41/64), respectively. A significant correlation was found among the expression of PRRX1, Smad2, E-cadherin, and vimentin (P < 0.05). Expression of the PRRX1, Smad2, and vimentin protein in gastric cancer tissue was correlated with Borrmann classification, lymph node-positive number, the degree of differentiation, depth of tumor invasion, and serum pepsinogen I (PGI) level (P < 0.05), but not with age, sex, serum carcinoembryonic antigen, serum CA199, or PGI/PGII (P > 0.05). Conclusion The positive rate of PRRX1 protein expression was positively correlated with the protein expression of Smad2 and vimentin, but negatively correlated with E-cadherin protein. PRRX1, Smad2, and vimentin proteins are associated with Borrmann type, lymph node positives, histologic grade, depth of tumor invasion, and serum PGI levels, all of which contribute to a poor prognosis for patients with gastric cancer.