文献类型：期刊文献

中文题名：糖脂平颗粒的制备工艺优选

英文题名：Optimization of Preparation Technology of Tangzhiping granules

作者：罗文蓉[1];杨扶德[2];金智生[2]

第一作者：罗文蓉

机构：[1]甘肃省中医院,兰州730050;[2]甘肃中医学院,兰州730000

第一机构：甘肃省中医院,兰州730050

年份：2013

卷号：19

期号：23

起止页码：11

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2011】；

基金：教育部重点项目(206150);甘肃省科技支撑计划项目(0708NKCA127)

语种：中文

中文关键词：糖脂平颗粒;提取工艺;喷雾干燥;超微粉碎;正交试验;辅料;挥发油

外文关键词：Tangzhiping granules;extraction technology;spray drying;ultrafine grinding;orthogonal test;accessories;volatile oil

摘要：目的： 优选糖脂平颗粒的水提取工艺和成型工艺。 方法： 以红芪总多糖含量为考察指标，通过L9（34）正交试验考察加水量、提取时间、提取次数对糖脂平颗粒水提取工艺的影响;以吸湿率、成型性、休止角及制粒情况为考察指标，采用单因素试验考察稀释剂、矫味剂、润湿剂种类及用量对糖脂平颗粒成型工艺的影响。采用固定漏斗法测定休止角。 结果： 优选的水提取工艺条件为加10倍量水提取2次，每次2 h。喷雾干燥工艺为喷雾干燥的工艺条件为提取液减压浓缩至相对密度1.05~1.10（60℃），进液物料温度50~60℃，进风口温度170℃，出风口温度85℃;水蛭、僵蚕超微粉碎，丹皮挥发油采用β-CD包合，以91%乙醇为润湿剂，药粉-稀释剂（1∶0.3），矫味剂用量2.0%。 结论： 优选的工艺合理可行，适用于糖脂平颗粒的制备。
Objective： To optimize water extraction technology and molding process of Tangzhiping granules. Method： With the content of total polysaccharides form Hedysari Radix as index,L9（34） orthogonal test was used to optimize water extraction process of Tangzhiping granules by taking water amount,extraction time and times as factors;With moisture absorption rate,formability,angle of repose and granulation as indexes,single factor tests were adopted to investigate effects of kind and amount of diluents,flavoring agents and wetting agents on molding technology.Angle of repose was determined by fixed funnel method. Result： Optimum water extraction process was as following：extracted 2 times with 10-folds the amount of water,2 h per time.Spray drying process was as following：the relative density of extract 1.05-1.10（60℃）,material temperature 50-60℃,inlet temperature 170℃,outlet temperature 85℃;Ultrafine grinding of Hirudo and Bombyx Batryticatus,volatile oil from Moutan Cortex was prepared β-CD clathrate,with 91% ethanol as wetting agent,powder-diluent（1：0.3）,flavoring agent 2%. Conclusion： Optimized process was reasonable,feasible and applicable to preparation of Tangzhiping granules.