文献类型：期刊文献

英文题名：Prognostic value of lymph node micrometastasis in esophageal cancer: A systematic review and meta-analysis

作者：Yang, Jing[1,2,3];Liu, Qianqian[1,2,3];Bai, Yuping[1,2,4];Zhao, Haitong[5];He, Tingting[1,2,3];Zhao, Ziru[1,2,3];Huang, Min[1,2,3];Jiang, Mengyuan[1,2,3];Zhang, Rui[1,2,3];Zhang, Min[1,2]

第一作者：Yang, Jing;杨晶;杨静

通信作者：Zhang, M[1];Zhang, M[2]

机构：[1]Gansu Univ Tradit Chinese Med, Sch Basic Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Pathol, Lanzhou, Gansu, Peoples R China;[3]940th Hosp Joint Logist Support Force Chinese Peop, Dept Pathol, Lanzhou, Peoples R China;[4]Hainan Prov Hosp, Dept Pathol, Haikou, Hainan, Peoples R China;[5]Lanzhou Univ, Evidence Based Social Sci Res Ctr, Sch Publ Hlth, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Sch Basic Med, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Pathol, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：12

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85146842468);WOS:【SCI-EXPANDED(收录号:WOS:000914856600001)】；

基金：Funding This study was supported by the National Natural Science Foundation of China (grant no 81860059). Basic Research Innovation Group Project of Gansu Province (No.22JR5RA709)

语种：英文

外文关键词：esophageal cancer; lymph node micrometastasis; prognosis; meta-analysis; systematic review

摘要：Objective: Whether lymph node micrometastasis (LNM) increases the risk in esophageal cancer patients remains controversial. We conducted a systematic review and meta-analysis to explore the prognosis value of LNM in esophageal cancer patients. Methods: Two reviewers independently searched electronic databases, including PubMed, Embase, and the Cochrane Library, for eligible citations until February 2022. We calculated pooled estimates of the hazards ratio with a random-effects model. The certainty of evidence was determined by the Grade of Recommendations Assessment, Development, and Evaluation (GRADE) method. A sensitivity analysis was performed to assess the stability. Publication bias was assessed using funnel plots and Egger's test. We also performed subgroup analysis to explore the source of heterogeneity. Results: A total of 16 studies, with 1,652 patients, were included. The overall survival (OS) was significantly increased with LNM negativity compared with LNM positivity (HR 1.95; 95% CI, 1.53-2.49; P < 0.001; I-2 = 0.0%, P = 0.930; certainty of evidence: low). Relapse-free survival (RFS) was significantly increased with LNM negativity compared with LNM positivity (HR 3.39; 95% CI, 1.87-6.16; P < 0.001; I-2 = 50.18%, P = 0.060; certainty of evidence: moderate). No significant difference was observed in recurrence between the two groups (certainty of evidence: low). Sensitivity analysis revealed a stable trend. In addition, the funnel plot and Egger's test did not show significant publication bias. Conclusion: LNM positivity worsens the prognosis in esophageal cancer, and the evidence for RFS is moderate. Future relevant high-quality studies are warranted to validate our results further and provide a reference for guidelines.