文献类型：期刊文献

中文题名：丹参酮ⅡA抗结肠癌作用机制研究进展

英文题名：Progress in search for mechanism of Tanshinone ⅡA's against colon cancer

作者：王秀月[1];赵川[1];李文静[2];陈彻[1];王勇[1];楚慧媛[1];梁永娟[1];李晶莹[1]

第一作者：王秀月

机构：[1]甘肃中医药大学临床医学院;[2]华北理工大学临床医学院

第一机构：甘肃中医药大学临床医学院

年份：2018

卷号：34

期号：5

起止页码：597

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD2017_2018】；

基金：甘肃省普通本科高校基本科研业务费专项基金资助项目([2014]63-15)

语种：中文

中文关键词：中药;丹参酮ⅡA;结肠癌;心血管疾病

外文关键词：traditional Chinese medicine ; Tanshinone ⅡA; colon cancer; cardiovascular disease

摘要：丹参酮ⅡA(TanⅡA)是从中药丹参及其同科同属植物中分离得到的单体化合物,具有抗氧化、抗动脉粥样硬化、抗肿瘤、减小心肌梗死面积、改善心肌耗氧量、抑制血栓形成、抑制血小板聚集等广泛的药理活性。在临床上主要用于治疗心血管疾病。丹参酮ⅡA在抑制结肠癌细胞增殖、促进细胞凋亡、促进细胞侵袭转移等方面具有突出的抗癌活性,使其成为医药界研究人员关注的热点。本文就丹参酮ⅡA的抗结肠癌作用研究进行综述。
Tanshinone Ⅱ A （ Tan Ⅱ A） is an extract of traditional Chinese medicine Salvia miltiorrhiza, which can play a natural antioxidant effect. It is mainly used in the treatment of cardiovascular disease. Which has anti -atherosclerosis, reduced myocardial infarct size and improve myocardial oxygen consumption, inhibition of thrombosis, inhibi- tion of platelet aggregation, antitumor activity and other effects, and are mainly used for the treatment of cardiovascular disease in clinical applications. In recent years, a large number of clinical studies and animal experiments have confirmed that tanshinoneⅡ A in the inhibition of colon cancer cell proliferation, promote cell apoptosis, promote cell invasion and metastasis and other aspects of prominent anti - cancer effect, making it the object of concern to researchers. In this paper, tanshinone Ⅱ A anti - colon cancer effect of studies were reviewed.