文献类型：期刊文献

英文题名：Angelica sinensis polysaccharide extends lifespan and ameliorates aging-related diseases via insulin and TOR signaling pathways, and antioxidant ability in Drosophila

作者：Tuo, Wenjuan[1,2,3];Wang, Shuwei[4];Shi, Yan[1,2,3];Cao, Wangjie[1,2,3,5];Liu, Yongqi[1,2,5];Su, Yun[1,2,5];Xiu, Minghui[4,5];He, Jianzheng[2,3]

第一作者：Tuo, Wenjuan

通信作者：He, JZ[1];He, JZ[2];Xiu, MH[3];Xiu, MH[4]

机构：[1]Gansu Univ Chinese Med, Prov level Key Lab Mol Med Major Dis, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Prevent & Treatment Tradit Chinese Med Res Gansu C, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China;[4]Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[5]Minist Educ, Key Lab Dunhuang Med, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prevent & Treatment Tradit Chinese Med Res Gansu C, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[4]corresponding author), Minist Educ, Key Lab Dunhuang Med, Lanzhou 730000, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;

年份：2023

卷号：241

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001001341700001)】；

基金：This work was supported by grants from the National Natural Science Foundation of China (No. 82004228) , the Foundation of Gansu Provincial Administration of Traditional Chinese Medicine (No. GZKZ- 2022-9) , the Central Guiding Local Science and Technology Development Fund Projects (No. 22ZY1QA003) , "Innovation Star" Project of Excellent Postgraduates in Gansu (No. 2022CXZX-751) , Gradutate Innovation and Entrepreneurship Fundation of Gansu University of Chinese Medicine (No. 2021CX34) .

语种：英文

外文关键词：Angelica sinensis polysaccharide; Healthy aging; Intestinal homeostasis; Sleep disorders; Alzheimer's disease

摘要：Angelica sinensis polysaccharide (ASP) is one of the principal active components of Angelica sinensis (AS) that is widely used in natural medicine and has various pharmacological activities, including antioxidant, anti-inflammatory, and enhancing immunity. However, its pharmacological role of anti-aging needs to be clarified. Here, we detected the beneficial effect and mechanism of ASP on healthy aging and aging-related diseases using the Drosophila melanogaster model. The results showed that oral administration of ASP remarkably extended lifespan, increased reproduction, improved climbing ability, and increased resistance to starvation and oxidative stress in aged flies, mainly via inhibiting insulin signaling (IIS) and TOR signaling and boosting antioxidant ability. Further, ASP supplementation protected against aging-induced intestinal homeostasis imbalance via inhibiting intestinal stem cells (ISCs) hyperproliferation and oxidative damage, improved sleep disorders via rescuing sleep rhythm in aged flies, and had a neuroprotective effect on A beta 42 transgenic flies. Taken together, our findings shed light on the possibility that ASP could increase lifespan, improve healthy aging, and ultimately reduce the incidence of age-related illnesses. It holds promise as a candidate for anti-aging intervention and treatment for aging-associated disorders.