文献类型：期刊文献

英文题名：Autophagy and mitophagy in diabetic retinopathy: The effects and mechanism of action on the neurovascular unit

作者：Ren, Yuyan[1];Zhang, Huazhi[1,2];Lan, Qingping[1];Tang, Jingwen[1];Li, Yilan[1];Wang, Ziying[1];Wang, Yapeng[2]

第一作者：Ren, Yuyan

通信作者：Ren, YY[1];Zhang, HZ[1]

机构：[1]Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp 2, Dept Ophthalmol, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：263

外文期刊名：EXPERIMENTAL EYE RESEARCH

收录：;Scopus(收录号：2-s2.0-105024672444);WOS:【SCI-EXPANDED(收录号:WOS:001643470700001)】；

基金：The author (s) declare that financial support was received for the research, authorship, and/or publication of this article. This research was supported by Gansu Provincial Natural Science Foundation Project (21JR1RA260) ; Evaluation of the Efficacy of Traditional Chinese Medicine Fumigation Therapy Combined with Artificial Tears in the Treatment of Dry Eye (GZFY-2022-16) ; Clinical Efficacy of Intradermal Needle, Auricular Acupressure, and Herbal Fumigation for MGD Dry Eye (2025CXCY-027)

语种：英文

外文关键词：Diabetic retinopathy (DR); Retinal neurovascular unit (NVU); Autophagy; Mitophagy

摘要：While diabetic retinopathy (DR) is the primary cause of vision impairment and blindness in people with diabetes, current treatments fail to target early pathogenic mechanisms to halt disease progression. The development of DR involves complex cellular stress responses associated with metabolic dysregulation. Recent studies have highlighted the critical functions of autophagy, particularly mitophagy, in DR and how it contributes to the malfunction of the retinal neurovascular unit (NVU) and disease progression. Emerging insights have elucidated the interplay between autophagy, ER stress, and regulatory genes such as DRAM2, with pivotal roles for mitophagy-related pathways, including PINK1/Parkin and BNIP3/NIX-FUNDC1. This review systematically organizes and analyzes recent advances in research on how autophagy and mitophagy regulate ER stress, mitochondrial homeostasis, and the function of diverse NVU cell types. We present evidence that dysregulation of these processes compromises NVU integrity and accelerates DR progression. By clarifying the molecular links between autophagy, mitophagy, and NVU dysfunction, this review offers new insights for developing precision interventions and innovative therapies for early intervention of DR.