文献类型：期刊文献

中文题名：OPG/RANK/RANKL通路在骨质疏松与动脉粥样硬化相关性中的作用机制研究进展

英文题名：Progress of Research on the Relationship of the Mechanism of Action Between Osteoporosis and Atherosclerosis in OPG/RANK/RANKL Pathway

作者：赵希云[1];张晓刚[1,2];宋敏[1];曹林忠[1];张宏伟[1];王志鹏[1];秦大平[1]

第一作者：赵希云

机构：[1]甘肃中医药大学;[2]甘肃中医药大学附属医院

第一机构：甘肃中医药大学

年份：2016

卷号：24

期号：12

起止页码：1273

中文期刊名：中国动脉硬化杂志

外文期刊名：Chinese Journal of Arteriosclerosis

收录：CSTPCD;;北大核心:【北大核心2014】；

基金：国家自然科学基金资助项目(81560780)

语种：中文

中文关键词：骨保护素;核因子κB受体活化因子;核因子κB受体活化因子配体;骨质疏松;动脉粥样硬化

外文关键词：Osteoprotegerin; Receptor Activator of NF-κB; Receptor Activator of NF-κB Ligand; Osteoporosis; Atherosclerosis

摘要：骨质疏松和动脉粥样硬化是伴随老年患者的常见疾病,发病率高,并发症多,是死亡率增加的主要危险因素。随着患者年龄的增加,二者的临床联系也越来越紧密。OPG/RANK/RANKL通路是近年来研究的热点,是骨质疏松研究史上里程碑式的发现。近年来逐渐认识到这种信号传导途径在动脉粥样硬化中同样起着不可估量的作用,研究者对该通路与动脉粥样硬化之间进行了潜在而广泛的研究。本文就OPG/RANK/RANKL通路作为它们之间联系的桥梁,初步探讨共同的发病机制及临床联系,为临床工作中以这些分子作为靶点设计和药物制备提供进一步的综合理念。
Osteoporosis and atherosclerosis are very common diseases associated with elder patients,it has higher incidence rate and more complications,they are the major risk factor for increased mortality.With the increasing of the patient＇s age,the clinical connections between them have become increasingly closer.In recent years,OPG/RANKL/RANK pathway is the research high lights and it is a milestone in the research history of osteoporosis.The researchers come to realize that this signal pathway also played an invaluable role in atherosclerosis,enabling researchers conduct extensive research potential between the system and atherosclerosis.This article is about OPG/RANKL/RANK pathway as a bridge connection between them,exploring their common pathogenesis and clinical relationships,for providing further integrated concept in clinical work with these molecules as targets for designing and generating new drugs.