文献类型：期刊文献

中文题名：铁死亡在中药治疗肝纤维化中的研究进展

英文题名：Ferroptosis in Treatment of Liver Fibrosis with Chinese Medicine:A Review

作者：郑兰兰[1];郭才[1];何燕芳[1];谢娇娇[1];高芬[1];于春[1];马燕花[1]

第一作者：郑兰兰

机构：[1]甘肃中医药大学第一临床医学院,兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2023

卷号：29

期号：23

起止页码：235

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金地区科学基金项目(81860821)。

语种：中文

中文关键词：铁死亡;中药;肝纤维化;研究进展

外文关键词：ferroptosis;Chinese medicine;liver fibrosis;research progress

摘要：肝纤维化是各种慢性肝损伤作用于肝脏,导致肝星状细胞异常活化,以细胞外基质蛋白的生成与降解失衡,过度沉积破坏肝脏正常结构为主要特征的一种疾病。随着肝纤维化程度的加重,可发展为不可逆性的肝硬化与肝细胞癌,已经成为全球健康面临的巨大挑战。铁死亡是近些年来研究发现的一种铁依赖性的新型细胞死亡方式,主要涉及铁离子代谢异常、脂质过氧化物堆积及抗氧化防御系统的减弱。有多项研究表明通过诱导肝星状细胞铁死亡或减轻肝脏铁死亡可改善肝纤维化,减轻肝损伤。随着中药在各种慢性肝病中的广泛应用,其安全性好、功效覆盖广、方便易得等特点逐渐显现出来,与西药相比,在治疗慢性病方面独具优势。因此,以中药干预肝星状细胞或肝脏铁死亡作为切入点或将是今后防治肝纤维化的新方向。该文整理了铁死亡发生的多种调控机制,探讨了铁死亡如何影响肝纤维化的进展,总结中药活性成分及复方等通过铁死亡途径对肝纤维化进程进行干预的现状与进展,为未来中药防治肝纤维化提供理论支持。
Hepatic fibrosis characterized by various chronic liver injuries can lead to abnormal activation of hepatic stellate cells,unbalanced production and degradation of extracellular matrix proteins,and excessive deposition that destroys the normal structure of the liver.The aggravated liver fibrosis can cause irreversible cirrhosis and hepatocellular carcinoma,becoming a great challenge to the global health.Ferroptosis is a new form of iron-dependent cell death discovered in recent years,which mainly involves abnormal iron metabolism,lipid peroxide accumulation,and weakening of the antioxidant defense system.A number of studies have reported that inducing ferroptosis in hepatic stellate cells or alleviating ferroptosis in the liver can ameliorate liver fibrosis and reduce liver injury.Chinese medicine widely applied in the treatment of chronic liver diseases has demonstrated good safety,wide therapeutic effects,and easy access compared with Western medicine.Therefore,The intervention of hepatic stellate cells or hepatic ferroptosis by Chinese medicine may be a new direction for the prevention and treatment of liver fibrosis in the future.This paper summarized the various regulatory mechanisms of ferroptosis and expounded how ferroptosis affected the progression of liver fibrosis,providing theoretical support for the prevention and treatment of liver fibrosis with Chinese medicine in the future.