文献类型：期刊文献

中文题名：葛根芩连汤对2型糖尿病肠道湿热证胰岛β细胞功能的影响

英文题名：Efficacy of the Gegen Qinlian decoction on pancreatic β-cell function of type 2 diabetes with intestinal damp-heat syndrome

作者：康学东[1];任伯达[2];高攀[2]

第一作者：康学东

机构：[1]甘肃中医药大学附属医院,甘肃兰州730020;[2]甘肃中医药大学,甘肃兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2022

卷号：14

期号：2

起止页码：75

中文期刊名：中医临床研究

外文期刊名：Clinical Journal Of Chinese Medicine

基金：2018年甘肃省中医药管理局科研项目(2018ZD04)。

语种：中文

中文关键词：β细胞功能;肠道湿热证;2型糖尿病;葛根芩连汤

外文关键词：β-cell function;Intestinal damp heat syndrome;Type 2 diabetes mellitus;The Gegen Qinlian decoction

摘要：目的:通过葛根芩连汤对初发2型糖尿病肠道湿热证的治疗,观察胰岛β细胞功能相关指标的变化,为中医药治疗该病提供客观依据。方法:本研究选取初发2型糖尿病肠道湿热证患者60例,随机分组,治疗组(30例)给予基础治疗联合葛根芩连汤治疗,对照组(30例)给予基础治疗联合二甲双胍治疗。观察治疗前后中医证候评分、身体质量指数、腰围、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、糖化血红蛋白、空腹血糖、餐后2小时血糖、胰岛素抵抗指数、胰岛素分泌指数的变化。结果:治疗前后对比,两组空腹血糖、餐后2小时血糖、糖化血红蛋白的差异有统计学意义(P<0.05,P<0.01);治疗后组间对比,对照组空腹血糖、糖化血红蛋白下降程度要好于治疗组(P<0.05),餐后2小时血糖的差异无统计学意义(P>0.05)。治疗前后对比,两组胰岛素抵抗指数的差异有统计学意义(P<0.05,P<0.01);治疗后两组胰岛素抵抗指数对比,对照组改善程度要好于治疗组(P<0.05)。两组胰岛素分泌指数治疗前后对比,差异无统计学意义(P>0.05)。治疗前后对比,治疗组三酰甘油的差异有统计学意义(P<0.05),对照组总胆固醇、低密度脂蛋白胆固醇的差异有统计学意义(P<0.05)。前后对比,治疗组中医证候评分的差异有统计学意义(P<0.05),对照组的差异无统计学意义(P>0.05)。两组腰围及身体质量指数治疗前后的差异有统计学意义(P<0.05,P<0.01);治疗后,对照组下降程度要好于治疗组(P<0.05)。结论:葛根芩连汤具有降低血糖、三酰甘油、腰围和身体质量指数,改善初诊2型糖尿病肠湿热证患者中医证候积分的作用,其降糖、降脂机制与改善胰岛素抵抗指数有关。
Objective:To observe the changes of islet β-cell function related indexes in treating intestinal damp heat syndrome of type 2 diabetes mellitus with the Gegen Qinlian decoction(葛根芩连汤),so as to provide objective basis for TCM treatment.Methods:60 cases were randomly divided into groups,the treatment group(30 cases)was treated by basic treatment plus the Gegen Qinlian decoction,and the control group(30 cases)was treated by basic treatment plus metformin.Results:Before and after treatment,the GLU,2 h PG and HbAlc in two groups were significantly different(P<0.05,P<0.01);after treatment,the decrease of GLU and HbAlc in the control group was better than the treatment group(P<0.05),but there was no significant difference in 2 h PG(P>0.05).Before and after treatment,HOMA-IR in two groups were significantly different(P<0.05,P<0.01);after treatment,the improvement of HOMA-IR in the control group was better than the treatment group(P<0.05).There was no significant difference between the two groups before and after treatment in insulin secretion index(P>0.05).Before and after treatment,TG in the treatment group was significantly different(P<0.05),TC and LDL-C in the control group were statistically different(P<0.05).Before and after treatment TCM syndrome score in the treatment group showed statistical difference(P<0.05),while the control group showed no statistical difference(P>0.05).Before and after treatment,waist circumference and BMI in two groups showed statistical difference(P<0.05,P<0.01);after treatment,the degree of decline in the control group was better than the treatment group(P<0.05).Conclusion:The Gegen Qinlian decoction can reduce blood glucose,triglyceride,waist circumference and body mass index,and ameliorate TCM syndrome score of patients with intestinal damp heat syndrome of type 2 diabetes mellitus,and its hypoglycemic and lipid-lowering mechanism was related to the improvement of HOMA-IR.