文献类型：期刊文献

中文题名：间充质干细胞及其外泌体在阿尔茨海默病中的研究进展

英文题名：Research progress of mesenchymal stem cells and their exosomes in Alzheimer's disease

作者：童生莲[1];张茜[1];石亚军[2];孙海燕[2];周士燕[2]

第一作者：童生莲

机构：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000;[2]中国人民解放军联勤保障部队第九四〇医院血液科,甘肃兰州730050

第一机构：甘肃中医药大学临床医学院

年份：2025

卷号：29

期号：16

起止页码：112

中文期刊名：实用临床医药杂志

外文期刊名：Journal of Clinical Medicine in Practice

基金：甘肃省自然科学基金项目(21JRIRA183);甘肃省卫生健康行业科研计划项目(GSWSKY2021-044);西北民族大学中央高校重大需求培育项目(31920220110);联勤保障部队第九四〇医院基础和临床培育项目(2021yxky042)。

语种：中文

中文关键词：间充质干细胞;外泌体;阿尔茨海默病;神经炎症;神经保护;神经再生;细胞治疗;认知功能改善

外文关键词：mesenchymal stem cells;exosomes;Alzheimer's disease;neuroinflammation;neuroprotection;neuroregeneration;cell therapy;cognitive function improvement

摘要：阿尔茨海默病(AD)是一种严重影响老年人生活质量的慢性神经退行性疾病,其主要病理特征包括β-淀粉样蛋白沉积形成老年斑、tau蛋白异常磷酸化导致的神经纤维缠结,以及广泛的神经元丢失和突触功能障碍。近年来,间充质干细胞(MSCs)及其外泌体(MSC-Exos)因其在神经退行性疾病治疗中的潜力而引起广泛关注。MSCs具备多向分化潜能、免疫调节能力及显著的神经保护与修复作用。作为MSCs重要的信号传递介质,MSC-Exos是一类由MSCs分泌的纳米级双层膜结构囊泡,能够携带并传递多种生物活性物质。MSCs及其衍生的MSC-Exos在AD治疗中展现出良好的安全性和有效性,本文将系统综述近年来关于MSCs及MSC-Exos在AD治疗中的基础与转化研究进展。
Alzheimer's disease(AD)is a chronic neurodegenerative disease that severely affects the quality of life of the elderly.Its main pathological features include the deposition of β-amyloid protein to form senile plaques,neurofibrillary tangles caused by abnormal phosphorylation of tau protein,as well as extensive neuronal loss and synaptic dysfunction.In recent years,mesenchymal stem cells(MSCs)and their exosomes(MSC-Exos)have attracted extensive attention due to their potential in the treatment of neurodegenerative diseases.MSCs possess multidirectional differentiation potential,immunomodulatory capacity,and significant neuroprotective and repair effects.As an important signaling mediator of MSCs,MSC-Exos are a type of nanoscale double-layer membrane-structured vesicles secreted by MSCs,capable of carrying and delivering various bioactive substances.MSCs and their derived MSC-Exos have demonstrated good safety and efficacy in the treatment of AD.This article systematically reviewed the basic and translational research progress on MSCs and MSC-Exos in the treatment of AD in recent years.