文献类型：期刊文献

中文题名：细胞外信号调节激酶与肿瘤的关系及其抑制剂的研究进展

英文题名：Progress of the Correlation of Extracellular Signal-Regulated Kinase with Tumors and Its Inhibitors

作者：刘芳[1];赵川[1];陈彻[1];刘佳佳[1]

第一作者：刘芳

机构：[1]甘肃中医药大学临床医学院

第一机构：甘肃中医药大学临床医学院

年份：2019

卷号：9

期号：2

起止页码：184

中文期刊名：肿瘤药学

外文期刊名：Anti-tumor Pharmacy

收录：CSTPCD;;Scopus

基金：国家自然科学基金资助项目(81460456)

语种：中文

中文关键词：细胞外信号调节激酶;肿瘤;抑制剂

外文关键词：Extracellular signal-regulated kinase;Cancer;Inhibitors

摘要：细胞外信号调节激酶(ERK)是信号转导通路的重要分子,主要功能是把细胞外的信号通过磷酸化逐级传递至细胞核,参与细胞多种生物学行为。研究表明ERK1/2在肝癌、乳腺癌、前列腺癌以及宫颈癌等多种肿瘤组织和细胞中异常活化或过度表达,与肿瘤的发生发展有关。ERK1/2靶向抑制也成为近年肿瘤治疗的研究热点。本文主要就ERK1/2与肝癌、胃癌、宫颈癌的关系及相关ERK1/2抑制剂的研究进展进行综述。
Extracellular signal-regulated kinase(ERK) is a significant molecule of signal transduction pathway. Its main function is to transfer extracellular signals step by step to the nucleus through phosphorylation and participate in many biological behaviors of cells.Studies have shown that ERK1/2 is abnormally activated or over-expressed in various tumor tissues and cells such as liver cancer, breast cancer, prostate cancer and cervical cancer. Its abnormal molecular activation is related to the occurrence and development of tumors.Therefore, ERK1/2 targeted inhibition has also become a research hotspot in cancer therapy in recent years. This review focuses on the relationship between ERK1/2 and liver cancer, gastric cancer, cervical cancer and the related ERK1/2 inhibitors.