文献类型：期刊文献

英文题名：Treatment activity of a mixed-ligand coordination polymer on gastric carcinoma

作者：Shi, Yuhong[1];Wang, Gongchen[2]

第一作者：石育弘

通信作者：Wang, GC[1]

机构：[1]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Surg Dept, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Oncol Dept, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp, Oncol Dept, Lanzhou, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2022

卷号：99

期号：5

外文期刊名：JOURNAL OF THE INDIAN CHEMICAL SOCIETY

收录：;Scopus(收录号：2-s2.0-85126517442);WOS:【SCI-EXPANDED(收录号:WOS:000793539400005)】；

基金：Not applicable.

语种：英文

外文关键词：Coordination polymer; Gastric carcinoma; Proliferation; VEGF signaling Pathway; Molecular docking

摘要：Reaction of 4,4'& nbsp;,4 "& nbsp;-nitrilotribenzoic acid (H3L), a C-3-symmetric ligand, with the divalent Co(II) salt Co (NO3)(2).& nbsp;6H(2)O in the present of the N-donor ligand 1,2-di(4-pyridyl)ethylene (DPE) affords a new mixed-ligand coordination polymer with the chemical formula of [Co-3(TNB)(DPE)(2)].& nbsp;2H(2)O.& nbsp;DMF (1). In this study, CCK-8 assay was used to determine the effect of novel compound on proliferation of gastric cancer cells. The VEGF signaling pathway in gastric cancer cells was determined through employing real-time PCR after treatment of the above complex. Further, molecular docking simulation confirmed that the biological activity was coming from the carboxyl groups through the hydrogen bonding interactions with the receptor protein, the pyridine group only bonded with the Co ion for the formation of the Co complex.