文献类型：期刊文献

英文题名：Diagnostic value of urinary albumin creatinine ratio in predicting vision-threatening diabetic retinopathy in patients with diabetes: a systematic review and Meta-analysis

作者：Gao, Ying[1];Zhuang, Jia-Yuan[1,2,3];Ren, Yu-Yan[1];Zhang, Hua-Zhi[1];Hu, Yi-Ming[1];Li, Cheng-Hao[2,3,4];Hu, Mei[1,2,3];Zhou, Heng[2,3];Luo, Xiang-Xia[5]

第一作者：高瑛;高英

通信作者：Luo, XX[1];Zhou, H[2]

机构：[1]Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]Yangzhou Univ, Sch Publ Hlth, Yangzhou 225009, Jiangsu, Peoples R China;[3]Yangzhou Univ, Sch Nursing, Yangzhou 225009, Jiangsu, Peoples R China;[4]Yangzhou Univ, Sch Med, Yangzhou 225000, Jiangsu, Peoples R China;[5]Gansu Univ Chinese Med, Affiliated Hosp 1, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp 1, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Yangzhou Univ, Yangzhou 225000, Jiangsu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：19

期号：9

起止页码：1800

外文期刊名：INTERNATIONAL JOURNAL OF OPHTHALMOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001856456200016)】；

基金：Foundations: Supported by the Natural Science Foundation of Gansu Province (No.24JRRA566) ; National Natural Science Foundation of China (No.81960888) ; Gansu Provincial Key R&D Program (No.20YF3FA019) ; Excellent Doctoral Program of Gansu Natural Science Foundation (No.23JRRA1223) .

语种：英文

外文关键词：vision-threatening diabetic retinopathy; albumin excretion rate; urinary albumin creatinine ratio; estimated glomerular filtration rate

摘要：circle AIM: To evaluate the predictive value of urinary albumin creatinine ratio (UACR), albumin excretion rate (AER), and estimated glomerular filtration rate (eGFR) for vision-threatening diabetic retinopathy (VTDR) in individuals with diabetes. circle METHODS: A comprehensive literature search across PubMed, Embase, Web of Science, Scopus, and the Cochrane Library from their inception to February 2024 were performed. The diagnostic accuracy of microalbuminuria (MA; including UACR and AER) and eGFR in predicting VTDR using sensitivity, specificity, positive likelihood ratio and negative likelihood ratio, diagnostic odds ratio (DOR), and the area under the summary receiver operating characteristic (ROC) curve were assessed. Analyses incorporated both bivariate generalized linear mixed models and random-effects models to ensure a robust and unbiased interpretation of the data. circle RESULTS: The review included 14 studies with a total of 87 223 patients. The pooled sensitivity and specificity of MA and eGFR for predicting VTDR were 0.77 [95% confidence interval (CI), 0.57-0.89] and 0.51 (95%CI, 0.31-0.72), respectively. The DOR was 3.47 (95%CI, 1.94-6.18), with the area under the summary ROC curve at 0.70 (95%CI, 0.66-0.74). Notably, UACR as a predictor showed a sensitivity of 0.88 (95%CI, 0.43-0.99) and specificity of 0.55 (95%CI, 0.22-0.84), with an area under the curve of 0.78 (95%CI, 0.74-0.82). Despite significant heterogeneity among the studies (P<0.01), no publication bias was detected. circle CONCLUSION: UACR is a highly sensitive but moderately specific indicator for early detection and management strategies in this high-risk population.