文献类型：期刊文献

英文题名：Advances in the relationship between ferroptosis and epithelial-mesenchymal transition in cancer

作者：Mu, Wenrong[1];Zhou, Zubang[2];Shao, Liping[2];Wang, Qi[2];Feng, Wanxue[1];Tang, Yuling[1];He, Yizong[1];Wang, Yuanlin[1]

第一作者：Mu, Wenrong

通信作者：Zhou, ZB[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Ultrasound, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Ultrasound, Lanzhou, Gansu, Peoples R China.

年份：2023

卷号：13

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85177429456);WOS:【SCI-EXPANDED(收录号:WOS:001104946900001)】；

基金：Thanks to all the authors for their contribution to this study.r The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Gansu Provincial Science and Technology Department Key Research and Development Project, Grant Number: 22YF7FA098, Gansu Province Outstanding Graduate Student "Innovation Star" Project, Grant Number: 2022CXZX-744, Lanzhou City Talent Innovation and Entrepreneurship Project in Gansu Province, Grant Number:2019-RC-119, and 2021 Gansu Province Higher Education Innovation Fund Project, Grant Number:2021B-228.

语种：英文

外文关键词：ferroptosis; epithelial-mesenchymal transition; chemoresistance; mechanism; malignancy

摘要：Epithelial-mesenchymal transition (EMT) is a cellular reprogramming process that converts epithelial cells into mesenchymal-like cells with migratory and invasive capabilities. The initiation and regulation of EMT is closely linked to a range of transcription factors, cell adhesion molecules and signaling pathways, which play a key role in cancer metastasis and drug resistance. The regulation of ferroptosis is intricately linked to various cell death pathways, intracellular iron homeostasis, and the protein network governing iron supply and storage. The ability of ferroptosis to disrupt cancer cells and overcome drug resistance lies in its control of intracellular iron ion levels. EMT process can promote the accumulation of iron ions, providing conditions for ferroptosis. Conversely, ferroptosis may impact the regulatory network of EMT by modulating transcription factors, signaling pathways, and cell adhesion molecules. Thus, ferroptosis related genes and signaling pathways and oxidative homeostasis play important roles in the regulation of EMT. In this paper, we review the role of ferroptosis related genes and their signaling pathways in regulating cancer EMT to better understand the crosstalk mechanism between ferroptosis and EMT, aiming to provide better therapeutic strategies for eradicating cancer cells and overcoming drug resistance.