文献类型：期刊文献

英文题名：Integrative pan-cancer analysis indicates the prognostic importance of long noncoding RNA SNHG17 in human cancers

作者：Zhang, Guangming[1,2,3,4];Fu, Liangyin[1,2,3,4];Wang, Yongfeng[4];Liu, Bin[4];Ma, Shixun[4];Ma, Haizhong[4];Zhang, Helin[1];Zhang, Fan[1];Yang, Kehu[5];Cai, Hui[1,2,3,4,6,7]

第一作者：Zhang, Guangming

通信作者：Cai, H[1]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou 730000, Peoples R China;[2]Gansu Prov Hosp, Gen Surg Clin Med Ctr, Lanzhou 730000, Peoples R China;[3]Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou 730000, Peoples R China;[4]Gansu Prov Hosp, Lanzhou 730000, Peoples R China;[5]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China;[6]Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou 730000, Peoples R China;[7]204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2022

卷号：238

外文期刊名：PATHOLOGY RESEARCH AND PRACTICE

收录：;Scopus(收录号：2-s2.0-85138624675);WOS:【SCI-EXPANDED(收录号:WOS:000870884300001)】；

基金：This study was supported by grants from Key talent project of Gansu Province of the Organization Department of Gansu provincial Party committee (2020RCXM076); Key Laboratory of gastrointestinal cancer diagnosis and treatment of National Health Commission (2019PT320005); The 2021 Central-Guided Local Science and Technology Development Fund (ZYYDDFFZZJ-1); Gansu Provincial Youth Science and Technology Fund Program (21JR7RA642); Gansu Key Laboratory of molecular diagnosis and precision treatment of surgical tumors (18JR2RA033); Lanzhou talent innovation and Entrepreneurship Project (2016-RC-56); Fundamental Research Funds for the Central Universities (2020jbkyzx001; lzujbky-2020-kb20); Gansu University of Chinese Medicine Postgraduate "Innovation Fund" project (2022CX52); Natural Science Foundation of Gansu Province (21JR11RA186).

语种：英文

摘要：Background: Cancer is one of the most widespread causes of death today. Early diagnosis can dramatically reduce cancer-related mortality. Studies have shown that the lncRNA Small Nucleolar RNA Host Gene 17 (SNHG17) is aberrantly expressed in various types of solid tumors. Nevertheless, its prognostic value remains to be elucidated. The main objective of this meta-analysis was to elucidate whether SNHG17 can be considered as a potential prognostic biomarker for a variety of cancers. Methods: Correlational studies were screened from Cochrane, Embase, PubMed, and Web of Science. Hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were pooled, and the role of SNHG17 in cancer was analyzed. The Cancer Genome Atlas (TCGA) database was employed to verify the results. Results: Seventeen original papers including 1451 patients were included in the meta-analysis. SNHG17 expression was upregulated in various cancers. Over -expression of SNHG17 was significantly correlated with worse overall survival (OS) (HR = 1.92, 95% CI 1.55-2.37, P < 0.001) and relapse-free survival (RFS) (HR = 1.87, 95% CI 1.06-3.30, P = 0.030). Furthermore, overexpression of SNHG17 was predictive of earlier lymph node metastasis (LNM) (OR = 2.94, 95% CI 2.29-3.78, P < 0.001), more advanced tumor-node-metastases (TNM) stage (OR = 3.56, 95% CI 2.22-5.68, P < 0.001), larger tumor size (OR = 2.18, 95% CI 1.65-2.88, P < 0.001), worse differentiation grade (OR = 1.69, 95% CI 1.26-2.25, P < 0.001), and earlier distant metastasis (DM) (OR = 1.63, 95% CI 1.03-2.56, P = 0.033) in human cancers. Moreover, further inquiry based on TCGA dataset validated that SNHG17 was high expression in various tumors and foresaw unfavorable clinical prognosis. Conclusions: Overexpression of SNHG17 correlates with poor prognosis and advanced clinicopathological features in cancer patients and may be a potential prog-nostic indicator and a therapeutic target for cancer treatment.