文献类型：期刊文献

英文题名：Antipyretic Effect of Geniposide in Dry Yeast-Induced Pyrexia Rats via Intervening the Compositions of Gut Microbiota

作者：Li, Xiao-lin[1,2];Chen, Sheng-fu[4];Liu, Tian-long[2];Wang, Ren-jie[1];Wang, Rong[2];Li, Mao-Xing[1,3,5]

第一作者：Li, Xiao-lin;李小林

通信作者：Li, MX[1];Wang, R[2];Li, MX[3];Li, MX[4]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[2]940 th Hosp Joint Logist Support Force, Gansu Plateau Pharmaceut Technol Ctr, Dept Pharm, Lanzhou, Peoples R China;[3]Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing, Peoples R China;[4]Sanya Peoples Hosp, Dept Pharm, Sanya, Peoples R China;[5]Beijing Inst Radiat Med, Natl Key Lab Kidney Dis, Beijing, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[2]corresponding author), 940 th Hosp Joint Logist Support Force, Gansu Plateau Pharmaceut Technol Ctr, Dept Pharm, Lanzhou, Peoples R China;[3]corresponding author), Beijing Inst Radiat Med, Dept Pharmaceut Sci, Beijing, Peoples R China;[4]corresponding author), Beijing Inst Radiat Med, Natl Key Lab Kidney Dis, Beijing, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2026

卷号：60

期号：4

起止页码：1636

外文期刊名：INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH

收录：;Scopus(收录号：2-s2.0-105051573133);WOS:【SCI-EXPANDED(收录号:WOS:001880186400030)】；

基金：This work was supported by the Young Scientists Fund of Gansu Province (25JRRA816,23JRRA1676) and the Gansu Provincial Health Care Research Projects (GSWSKY2022-46) .

语种：英文

外文关键词：Geniposide; Gut Microbiota; 16S rDNA; Antipyretic

摘要：Aim: Geniposide is the main active ingredient in Gardenia jasminoides Ellis, but its antipyretic mechanism is still unclear. Materials and Methods:To study the change of the gut microbiota in febrile rats with dry yeast-induced and antipyretic of geniposide based on 16SrDNA sequencing, 24 male screening SD rats were randomly and equally divided into normal control group (NG, Sterile water for injection, 10 mL/kg); fever model group (MG, Sterile water for injection, 10 mL/ kg); Geniposide group (GG, 100 mg/kg); Aspirin group (AG, 100 mg/kg).The MG, GG, and AG were prepared the fever model with dry yeast. After5 hrofsubcutaneous application with 20% dry yeast suspension (10 mL/kg) to the back neck, the drug was given by intragastric administration. After 5 hr of administration, the colon contents of rats were collected, and the changes in gut microbiota composition and species abundance were detected by 16SrDNA sequencing technology. Results: Fever significantly upregulates Bacillis, Lactobacillales, Lactobacillus, Lachnospiracea incertaesedis, Lactobacillus apodemi and Eubacterium uniforme in rats, whereas fever significantly reduced Coprobacillus, Prevotellaceae Coprobacillus cateniformis and Oscillibacter ruminantium., The results were reversed after the administration of geniposide. Conclusion: Collectively, our study showed that the compositions of gut microbiota in febrile rats induced by dry yeast were change, and geniposide regulated the gut microbiota in febrile rats.