文献类型：期刊文献

中文题名：从“肝肾同调”探析黑逍遥散干预AD免疫炎症的研究思路

英文题名：Intervention of Hei Xiaoyaosan in Alzheimer’s Disease Immune Inflammation Based on Liver-kidney Homology

作者：王虎平[1];米彩云[1];周君[1]

第一作者：王虎平

机构：[1]甘肃中医药大学,兰州730000

第一机构：甘肃中医药大学

年份：2022

卷号：28

期号：17

起止页码：180

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金项目(81960828);甘肃省高等学校创新能力提升项目(2019B-100)。

语种：中文

中文关键词：阿尔茨海默病;黑逍遥散;研究思路;肝肾同调;免疫炎症;信号通路

外文关键词：Alzheimer’s disease;Hei Xiaoyaosan;research ideas;liver-kidney homology;immune inflammation;signal pathway

摘要：阿尔茨海默病(AD)是一种年龄高度相关的神经系统疾病,是造成老年期痴呆的最主要原因,亦是导致老年人丧失日常生活能力的最常见疾病,将给患者、家庭及社会带来沉重的精神负担和经济压力。中医可将其归属于“痴呆”“呆门”“呆病”等疾患范畴,传统认为以肾虚为本,多从肾论治。课题组结合肝的生理病理特性,提出了“肝肾同调”是防治AD的重要思路。AD以β淀粉样蛋白(Aβ)沉积和神经原纤维缠结(NFT)为主要病理表现,其发病机制复杂。越来越多的研究表明,免疫炎症在AD的发病过程中起着重要作用,通过核转录因子-κB(NF-κB)/NOD样受体热蛋白结构域3(NLRP3)/胱天蛋白酶-1(Caspase-1)/白细胞介素-1β(IL-1β)信号通路调控神经免疫炎症将是治疗AD的重要靶点。该文基于“肝肾同调”的重要思路,遴选其代表名方黑逍遥散,从调控NF-κB/NLRP3/Caspase-1/IL-1β信号通路进而抑制神经免疫炎症角度探析防治AD的作用与机制,以期进一步推进黑逍遥散防治AD的深入研究,亦为中医药防治AD的思路策略抛砖引玉。
Alzheimer’s disease(AD)is a neurological disease highly related to age,which is the main cause of senile dementia and the most common disease leading to the loss of daily living ability of the elderly.AD brings heavy mental burden and economic pressure to patients,families,and society.Traditional Chinese medicine(TCM)ascribes AD to category of "dementia",believing that the treatment should start from kidney because kidney deficiency is the root cause.Combined with the physiological and pathological characteristics of liver,this paper proposed that liver-kidney homology was an important idea for the prevention and treatment of AD.The main pathological manifestations of AD were amyloid β-protein(Aβ)deposition and neurofibrillary tangles(NFT),and the pathogenesis was complex.A growing number of studies showed that immune inflammation played an important role in the pathogenesis of AD.The important target of treating AD was the regulation of neuro-immune inflammation through the nuclear factor kappa B(NF-κB)/NOD-like receptor thermal protein domain associated protein 3(NLRP3)/Caspase-1/interleukin-1β(IL-1β) signaling pathway.Based on the idea of liver-kidney homology,this paper selected the representative formula Hei Xiaoyaosan to explore its effect on the prevention and treatment of AD and the mechanism from the perspective of regulating NF-κB/NLRP3/Caspase-1/IL-1β signaling pathway and inhibiting neuro-immune inflammation,expecting to further promote the in-depth study on the prevention and treatment of AD,and provide references for the prevention and treatment of AD by TCM.