文献类型：期刊文献

英文题名：Food and Medicine Homologous Plants in Osteoporosis: A Scoping Review of Preclinical Evidence

作者：Zhao, Long[1,2];Dong, Xiao-li[1,2];Li, Rui-ting[1,2];Ma, Qu-huan[1,2];Shi, Xiao-feng[1,2]

第一作者：赵磊;Zhao, Long

通信作者：Ma, QH[1];Shi, XF[1];Ma, QH[2];Shi, XF[2]

机构：[1]Gansu Univ Tradit Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[2]Gansu Acad Med Sci, Pharmaceut Res Inst, Lanzhou, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[2]corresponding author), Gansu Acad Med Sci, Pharmaceut Res Inst, Lanzhou, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2026

卷号：14

期号：6

外文期刊名：FOOD SCIENCE & NUTRITION

收录：;Scopus(收录号：2-s2.0-105041110565);WOS:【SCI-EXPANDED(收录号:WOS:001786633800001)】；

基金：This work was supported by the Lanzhou Science and Technology Bureau [2024-02-07].

语种：英文

外文关键词：estrogen; food and medicine homology; osteoporosis; oxidative stress

摘要：Osteoporosis is a chronic systemic bone disease characterized by reduced bone density and an increased risk of fractures. This review summarizes the preclinical evidence for 61 FMH plants and their active ingredients. Its bone protection mechanism involves estrogen-like action, inhibition of oxidative stress, regulation of intestinal flora and metabolites, regulation of autophagy, and other pathways. Based on a tertiary level of evidence, 24 plants had only a single animal/in vitro study (level 1), 34 had consistent results from multiple independent animal studies (level 2), and a few had preliminary human trials with obvious limitations (level 3). The existing evidence does not support FMH to replace standard anti-osteoporotic drugs and should be positioned as an adjunctive strategy for long-term prevention and early intervention, with standardized extracts and clinical trials with fractures as the endpoint in the future.