文献类型：期刊文献

中文题名：基于GBD 2021的中国肌肉骨骼疾病负担分析与趋势研究

英文题名：Analysis on the burden and trend of musculoskeletal diseases in China based on GBD 2021

作者：赵多伟[1];魏建仝[2];姜金[3];徐生刚[4];张辉[1,5]

第一作者：赵多伟

机构：[1]甘肃中医药大学第一临床医学院,兰州730000;[2]河西学院附属张掖人民医院骨科,甘肃张掖734000;[3]兰州大学第二医院骨科,兰州730000;[4]河西学院医学院,甘肃张掖734000;[5]甘肃省人民医院骨科,兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2025

卷号：34

期号：11

起止页码：1283

中文期刊名：药物流行病学杂志

外文期刊名：Chinese Journal of Pharmacoepidemiology

基金：国家自然科学基金地区项目(82160422);甘肃省科技计划资助项目(25JRRG006);甘肃省卫生健康行业科研项目(GSWSQN2024-21);河西学院校长基金创新团队项目(CXTD002);河西学院校长基金青年科研项目(QN2024031)。

语种：中文

中文关键词：肌肉骨骼疾病;痛风;骨关节炎;类风湿性关节炎;下腰痛;颈痛;疾病负担;变化趋势

外文关键词：Musculoskeletal diseases;Gout;Osteoarthritis;Rheumatoid arthritis;Low back pain;Neck pain;Burden of disease;Changing trend

摘要：目的分析1990—2021年中国肌肉骨骼疾病(包括痛风、下腰痛、颈痛、骨关节炎和类风湿性关节炎)的疾病负担及变化趋势,为制定和调整肌肉骨骼疾病的防护策略提供参考。方法利用2021年全球疾病负担(GBD 2021)数据库分析中国肌肉骨骼疾病发病率和伤残调整生命年(DALYs)率,采用年度百分比变化估计值(EAPC)综合评价1990—2021年中国肌肉骨骼疾病负担的变化趋势,并基于不同性别和年龄分层分析中国肌肉骨骼疾病的发病率和DALYs率。结果2021年中国痛风、下腰痛、颈痛、骨关节炎和类风湿性关节炎的发病人数分别为3079836、43374995、10292099、11652721和247307例。在5种主要肌肉骨骼疾病中,下腰痛的发病率和DALYs率最大。1990—2021年痛风、骨关节炎和类风湿性关节炎的年龄标化发病率呈上升趋势,颈痛的年龄标化发病率保持相对稳定,而下腰痛的年龄标化发病率呈下降趋势;痛风和骨关节炎的年龄标化DALYs率呈上升趋势,颈痛和类风湿性关节炎的年龄标化DALYs率保持相对稳定,而下腰痛的年龄标化DALYs率呈下降趋势。性别和年龄分层分析结果显示,男性痛风的年龄标化发病率和年龄标化DALYs率远高于女性,而女性下腰痛、颈痛、骨关节炎和类风湿性关节炎的年龄标化发病率和年龄标化DALYs率远高于男性;5种主要肌肉骨骼疾病负担集中年龄段相对一致,主要集中在40~75岁。结论1990—2021年中国痛风、骨关节炎和类风湿性关节炎的疾病负担明显加重,颈痛的疾病负担保持相对稳定,而下腰痛的疾病负担有所改善。此外,中国肌肉骨骼疾病负担在不同性别和年龄人群中存在较大差异。应尽快基于性别及年龄分层结果实施针对性干预措施,并加强健康宣教和改善基本医疗保健,以有效降低肌肉骨骼疾病负担。
Objective To analyze the burden and trend of musculoskeletal diseases(including gout,low back pain,neck pain,osteoarthritis,and rheumatoid arthritis)in China from 1990 to 2021,and to provide reference for formulating and adjusting prevention strategies for musculoskeletal diseases.Methods The Global Burden of Disease(GBD)in 2021 database was used to analyze the status and trend of the incidence and disability-adjusted life years(DALYs)rate of musculoskeletal diseases in China.Annual percentage change(EAPC)was used to comprehensively evaluate the trend of the burden of musculoskeletal diseases from 1990 to 2021.Gender and age-specific incidence and DALYs rate of musculoskeletal diseases were analyzed.Results In 2021,the number of cases of gout,low back pain,neck pain,osteoarthritis,and rheumatoid arthritis in China was 3,079,836,43,374,995,10,292,099,11,652,721,and 247,307,respectively.Among the 5 major musculoskeletal conditions,low back pain had the greatest incidence and DALYs rate.From 1990 to 2021,the age-standardized incidence of gout,osteoarthritis,and rheumatoid arthritis showed an upward trend,that of neck pain remained relatively stable,and that of low back pain showed a downward trend.The age-standardized DALYs rates of gout and osteoarthritis showed an increasing trend,that of neck pain and rheumatoid arthritis remained relatively stable,and that of low back pain showed a decreasing trend.The results of the stratified analysis by gender and age indicated that,the age-standardized incidence rate and agestandardized DALYs rate of gout were higher in men than in women,while the age-standardized incidence rate and age-standardized DALYs rate of low back pain,neck pain,osteoarthritis,and rheumatoid arthritis were higher in women than in men.The age groups with the burden of the five major musculoskeletal diseases were relatively consistent,mainly in the 40-75 years old.Conclusion From 1990 to 2021,the disease burden of gout,osteoarthritis,and rheumatoid arthritis increased significantly in China,while the disease burden of neck pain remained relatively stable,while the disease burden of low back pain showed a certain improvement.In addition,the burden of musculoskeletal diseases in China varies greatly by gender and age.Targeted intervention measures should be implemented as soon as possible based on the stratification results by gender and age,and health education and basic healthcare should be improved to effectively reduce the burden of musculoskeletal diseases.