文献类型：期刊文献

中文题名：基于神经炎症反应探讨肠道菌群与阿尔茨海默病相关研究进展

英文题名：Research progress on gut microbiota and Alzheimer’s disease based on neuroinflammatory responses

作者：张丽霞[1];张成舜[1];高亚雄[2];周强[2]

第一作者：张丽霞

机构：[1]张掖市中医院,甘肃张掖734000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：张掖市中医院,甘肃张掖734000

年份：2026

卷号：9

期号：2

起止页码：139

中文期刊名：阿尔茨海默病及相关病杂志

外文期刊名：Chinese Journal of Alzheimer's Disease and Related Disorders

基金：甘肃省临床重点专科能力提升项目(甘中医药医政函[2026]1号);兰州市科技发展指导性计划(2025-5-134);甘肃中医药大学附属医院针灸中心开放课题(ZJKF2220)。

语种：中文

中文关键词：阿尔茨海默病;肠道菌群;神经炎症反应

外文关键词：Alzheimer’s disease;Gut microbiota;Neuroinflammation

摘要：阿尔茨海默病(AD)以Aβ沉积、tau蛋白异常磷酸化及持续性神经炎症为关键病理特征,神经炎症贯穿疾病全程并与突触损伤和认知衰退密切相关。近年来研究发现,肠道菌群(GM)与AD的发生发展密切相关,尤其通过肠—脑轴可调节神经炎症反应对AD具有重要影响。因此,基于现有临床相关性研究与基础实验线索,本文重点梳理了GM介导神经炎症进而影响AD的多环节联动机制,系统综述了“GM-神经炎症-AD”轴的关键机制及潜在的干预策略,旨在为AD的临床防治提供治疗参考与理论依据。
Alzheimer’s disease(AD)is characterized by key pathological features including amyloid-β(Aβ)deposition,abnormal tau hyperphosphorylation,and persistent neuroinflammation.Neuroinflammation runs throughout the disease course and is closely associated with synaptic injury and cognitive decline.In recent years,accumulating evidence has indicated that the gut microbiota(GM)is closely linked to the onset and progression of AD,and that it can modulate neuroinflammatory responses via the gut-brain axis,thereby exerting an important influence on AD.Therefore,based on available clinical association studies and mechanistic insights from experimental research,this review focuses on the multi-step,integrated mechanisms by which GM-mediated neuroinflammation contributes to AD,and systematically summarizes the key mechanisms and potential intervention strategies targeting the“GM-neuroinflammation-AD”axis,aiming to provide therapeutic references and a theoretical basis for the clinical prevention and treatment of AD.