文献类型：期刊文献

中文题名：回生饮注射液对家兔急性心肌损害的保护作用

英文题名：The Protective Effects of Huishengyin Injection to Acute Myocardial Injury of Rabbits

作者：刘家骏[1];董文芳[1]

第一作者：刘家骏

机构：[1]甘肃中医学院心脑血管疾病研究室,兰州730000

第一机构：甘肃中医药大学

年份：1992

卷号：8

期号：6

起止页码：21

中文期刊名：中药药理与临床

外文期刊名：Pharmacology and Clinics of Chinese Materia Medica

收录：CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：回生饮注射液;抗心肌损害;心肌高Ca²⁺性损伤;Ca²⁺转运调节剂

外文关键词：myocardial injury-resistant ;myocardial injury induced by hypercalcium; calcium-transporting regulator

摘要：家兔静注回生饮注射液(HSI),可显著推迟肾上腺素(Ad)诱发的心肌缺血性损伤的发生时间,显著缩短损害持续时间;HSI在150mg/kg剂量下不能推迟垂体后叶素(PAH)诱发的心肌缺血性损害的发生时间,但可非常显著地缩短损害持续时间;可显著降低哇巴因(Oua)诱发的室速(VT)、室颤(VF)发生率与死亡率;可显著提高乌头碱(AC)致颤阈,并显著降低AC诱发的VF发生率与死亡率;HSI在150mg/kg剂量下不能降低CaCl_2所致的家兔心肌损害的死亡率,但可显著提高CaCl_2阈剂量,降低VF发生率,延长存活时间。以上结果表明HSI有显著预防家兔心肌损害作用。
The Hnishengyin intravenous injection (SHI) had significantly protective effects on myocardial injury of rabbits induced by adrenaline (Ad), pituitrin (P), ouabain (Oua), aconitine (AC), and CaCl2. The results were as follows: Occurring time of myocardial ischemic injury induced by adrenaline was delayed and sustened time of injury was rem-akbly shortened by HSI. HSI under a dosage of 150 mg/kg could not delay occurring time of myocardial ischemic injury induced by pituitrin but could shorten sustained time of injury remarkbly. HSI could also reduce occurring rate of ventricular tachycardia, ventricular fibrillation and death rate induced by ouabain significanty. The threshold of induced fibrillation increased remarkbly, occurring rate and death rate of AC-induced VF decreased. HSI under a dosage of 150 mg/kg could not reduce death rate of myocardial injury induced by CaCh but could increase threshold dosage, reduce occurring rate of VF, and prolong existent time.