文献类型：期刊文献

英文题名：Disulfidptosis and androgenic cancers: from molecular mechanisms to clinical applications and future translational research

作者：Wang, Xueyang[1];Zhao, Juan[1];Li, Qiming[1];Chang, Jiaqing[1];Zhao, Weiwei[1];Xing, Xiping[2]

第一作者：王小云;王小莹;王晓燕

通信作者：Wang, XY[1];Xing, XP[2]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2026

卷号：17

外文期刊名：FRONTIERS IN ENDOCRINOLOGY

收录：;Scopus(收录号：2-s2.0-105032176900);WOS:【SCI-EXPANDED(收录号:WOS:001710515600001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. Regional Science Fund Project of the National Natural Science Foundation of China (8256140296). Major Project of Gansu Provincial Administration of Traditional Chinese Medicine (GZKZ-2025-29). Major Scientific Research Project for Technological Innovation in the Health and Wellness Sector of Gansu Province (GSWSZD2024-18).

语种：英文

外文关键词：clinical applications; disulfidptosis; future transformation; male reproductive cancers; molecular mechanisms

摘要：Disulfidptosis, a newly discovered form of programmed cell death, has garnered significant attention in tumor biology and reproductive system research in recent years, particularly demonstrating importance in urological cancer studies. Prostate cancer, testicular cancer, and bladder cancer are highly prevalent malignant tumors among men globally. Modern medical research reveals their complex pathogenesis and the limited efficacy of traditional treatments, necessitating the identification of novel therapeutic targets. Disulfidptosis influences tumor cell survival and death by regulating the formation and cleavage of intracellular protein disulfide bonds, highlighting its pivotal role in tumorigenesis and progression. This paper systematically reviews the molecular mechanisms of disulfidptosis, elucidates its regulatory role in male cancer cells-including key regulatory genes and therapeutic target potential-and discusses its application value and challenges as a potential therapeutic target based on clinical research. It aims to deepen understanding of disulfidptosis regulation, provide new insights and strategies for future precision treatment and clinical translation of male cancers, and drive innovation in related therapeutic approaches.