文献类型：期刊文献

英文题名：Effect of thyroid dysfunction on N-terminal pro-B-type natriuretic peptide levels: A systematic review and meta-analysis

作者：Zhang, Hongling[1,2];Li, Xiaotao[2,3];Zhang, Nawen[1,2];Tian, Limin[1,2,4]

第一作者：Zhang, Hongling;张惠玲;张虎林

通信作者：Tian, LM[1];Tian, LM[2];Tian, LM[3]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Dept Endocrinol, Lanzhou, Peoples R China;[3]Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China;[4]Clin Res Ctr Metab Dis, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Endocrinol, Lanzhou, Peoples R China;[3]corresponding author), Clin Res Ctr Metab Dis, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：14

外文期刊名：FRONTIERS IN ENDOCRINOLOGY

收录：;Scopus(收录号：2-s2.0-85147748661);WOS:【SCI-EXPANDED(收录号:WOS:000935010300001)】；

基金：This work was supported by grant from the National Natural Science Foundation of China (No. 82060152)

语种：英文

外文关键词：NT-ProBNP; thyroid dysfunction; heart failure; systematic review; meta-analysis

摘要：Purpose: Thyroid hormones (THs) significantly affect the cardiovascular system. N -terminal pro-B-type natriuretic peptide (NT-proBNP) is a useful biomarker for diagnosing, evaluating, and predicting outcomes in heart failure (HF). This comprehensive review and meta-analysis aimed to investigate the effects of thyroid dysfunction (hypothyroidism and hyperthyroidism) on NT-proBNP levels.Methods: Two investigators independently searched PubMed, Embase, Cochrane Library, and Web of Science databases for studies published from inception to July 31, 2022, without any restrictions on language.Results: 21 studies were included. In participants without HF, NT-proBNP levels may be elevated in those with overt hyperthyroidism (standardized mean difference [SMD] 2.38, 95% confidence interval [CI]:1.0-3.76). Notably, among patients with preexisting HF, significantly higher NT-proBNP levels were found in patients with overt hyperthyroidism, overt hypothyroidism, or subclinical hypothyroidism than in euthyroid subjects (SMD [95%CI] = 0.31[0.01, 0.62], 0.32 [0.08, 0.56], and 0.33[0.21, 0.46], respectively). Seven trials compared NT-proBNP levels in patients with thyroid dysfunction before and after therapy, and significant drops in NT-proBNP levels were observed in patients with hyperthyroidism (SMD [95%CI] =-1.53[-2.50,-0.55]) upon achieving a euthyroid state. In contrast, increased NT-proBNP levels were observed in hypothyroid patients after treatment (SMD [95%CI] = 1.07[0.28, 1.85]).Conclusion: Thyroid dysfunction can significantly affect NT-proBNP levels, which may change upon achieving a euthyroid state. Notably, the effect of thyroid dysfunction on cardiac function may depend on the underlying cardiac status. Thus, timely recognition and effective treatment of cardiac symptoms in patients with thyroid dysfunction are mandatory because the prognosis of HF may be improved with appropriate treatment of thyroid dysfunction.