文献类型：期刊文献

英文题名：Sodium tanshinone IIA sulfonate attenuates radiation-induced fibrosis damage in cardiac fibroblasts

作者：Gu, Jing[1,2];Li, Hai-Long[1,2];Wu, Hong-Yan[1,2];Gu, Mei[3];Li, Ying-Dong[4];Wang, Xiao-Gang[5];Ming, Hai-Xia[4];Dong, Xiao-Li[4];Liu, Kai[4]

第一作者：顾静;Gu, Jing

通信作者：Liu, K[1]

机构：[1]Gansu Univ Tradit Chinese Med, Key Lab TCM Pharmacol & Toxicol Gansu Prov, Lanzhou 730000, Peoples R China;[2]New Prod Tradit Chinese Med Engn Lab Gansu Prov, Lanzhou 730000, Peoples R China;[3]Xiaoman Middle Sch Gansu Zhangye, Zhangye 734012, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Inst Integrated Tradit Chinese & Western Med, Lanzhou 730000, Peoples R China;[5]Lanzhou Univ, Inst Integrated Tradit Chinese & Western Med, Sch Basic Med Sci, Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Inst Integrated Tradit Chinese & Western Med, Lanzhou 730000, Peoples R China.|[10735ed249c6606940a33]甘肃中医药大学中西医结合学院;[10735]甘肃中医药大学;

年份：2014

卷号：16

期号：9

起止页码：941

外文期刊名：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录：;Scopus(收录号：2-s2.0-84907592857);WOS:【SCI-EXPANDED(收录号:WOS:000342302800007)】；

基金：The work was supported by the Natural Science Foundation of Gansu Province of China [NO.1310RJZA088], Fundamental Research Funds for Gansu Universities of China [No.GZY2012-1],the Project of Key Laboratory of TCM Pharmacology and Toxicology of Gansu Province [NO.ZDSYS-ZZKJ-2013(B)-004],and Youth Foundation of Gansu university of Traditional Chinese Medicine [No. ZQ2011-15].

语种：英文

外文关键词：radiation-induced fibrosis damage; cardiac fibroblasts; ROS; ER stress; TGF-beta 1

摘要：The main pathological change in radiation-induced heart disease is fibrosis. Emerging evidence has indicated that sodium tanshinone IIA sulfonate (STS) was used for treating fibrosis diseases. The present study was undertaken to characterize the effect of STS on radiation-induced cardiac fibrosis (RICF) on cultured cardiac fibroblasts (CFs). CFs were irradiated with 1 or 2 Gy X-rays, and the expression of TGF-beta 1 and collagen I (Col-1) increased, indicating that low-dose X-rays promoted fibrosis damage effect. The fibrosis damage was accompanied by morphologic changes in the endoplasmic reticulum (ER), as well as an increase in the expression of the ER stress-related molecules, GRP78 and CHOP. Administration of STS reduced ROS production and decreased the expression of Col-1, TGF-beta 1, p-Smad2/3, GRP78, and CHOP in irradiated CFs, thus weakening the radiation-induced fibrosis damage and ER stress. Radiation-induced fibrosis damage was observed on a cellular level. The involvement of ER stress in radiation-induced fibrosis damage was demonstrated for the first time. STS attenuated the fibrosis damage effect in CFs and this effect may be related to its antioxidant action, and also related to its inhibition of ER stress and TGF-beta 1-Smad pathway. These results suggest that STS shows a good prospect in clinical prevention and treatment of RICF.