文献类型：期刊文献

中文题名：苦瓜胶囊治疗2型糖尿病胰岛素抵抗的临床观察

英文题名：Clinical Observation on Function of KuGua Capsule for Improving Insulin Resistance in Patients with Type Two Diabetes Mellitus

作者：安小平[1];崔庆荣[1];康学东[1]

第一作者：安小平

机构：[1]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2017

卷号：30

期号：3

起止页码：1

中文期刊名：西部中医药

外文期刊名：Western Journal of Traditional Chinese Medicine

收录：CSTPCD

基金：2011年甘肃省中医药管理局科研项目(编号GZK-2011-25)

语种：中文

中文关键词：2型糖尿病;胰岛素抵抗;苦瓜胶囊;治疗,临床研究性

外文关键词：type two diabetes mellitus;insulin resistance;KuGua capsule;treatment

摘要：目的:观察苦瓜胶囊联合西药治疗2型糖尿病胰岛素抵抗的临床疗效。方法:将2型糖尿病患者86例按随机、单盲原则分为治疗组、对照组各43例;治疗组在西药治疗的同时加服苦瓜胶囊,对照组予单纯西药治疗,疗程为14周。观察2组患者糖化血红蛋白(HbA_(1c))、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)、糖负荷后30分钟胰岛素净增值/葡萄糖净增值(△I30/△G30)。结果:1)2组患者治疗后HbA_(1c)、血糖较治疗前均明显改善(P<0.05),2组治疗后比较差异有统计学意义(P<0.05);2)2组患者治疗后空腹胰岛素、C肽及服糖后30分钟胰岛素、C肽较治疗前均明显改善(P<0.05),2组治疗后比较差异有统计学意义(P<0.05);3)2组患者治疗后HOMA-IR、HOMA-β、糖负荷后30分钟△I30/△G30较治疗前均明显改善(P<0.05),2组治疗后比较差异有统计学意义(P<0.05);4)2组患者治疗后总胆固醇(TC)、甘油三酯(TG)、脂联素(APN)较治疗前均明显改善,且治疗组在改善TG、APN方面优于对照组(P<0.05)。结论:苦瓜胶囊联合西药改善2型糖尿病患者胰岛素抵抗的疗效优于单纯西药。
Objective：To observe the clinical effect of combination of KuGua （Momordica Charantia L.） ucapsule and western medicine for improving insulin resistance in patients with type two diabetes mellitus（T2DM ）. Methods： All 86 patients with T2DM were divided into the treatment group and the control group based on randomized and single blind principle, and 43 cases in each group. The treatment group was treated with western medicine and KuGua capsule at the same time, the control group was only treated with western medicine, and the treatment courses of both groups were 14 weeks. glycosylated hemoglobin （HbA1c）, insulin resistance index （HOMA-IR）, insulin secretion index （HOMA-β）, and the ratio of insulin net added value after 30min of glucose load with glucose net added value （△I30/△G30） of two groups were observed. Results：1） HbA1c and glucose levels of patients in two groups improved significantly before and after the treatment （P〈0.05）, and the differences were statistically significant （P〈0.05）;2） The levels of fasting insulin, Cpeptide, insulin and C peptide in 30min after taking glucose of the patients in two groups all improved significantly before and after treatment, and the differences between two groups were statistically significant （P〈0.05）; 3） HOMA-IR, HOMA-β and the ratio of insulin net added value after 30min of glucose load with glucose net added value （△I30/△G30） of patients in two groups all improved significantly before and after treatment, and the differences between two groups were statistically significant （P〈0.05）;4） TC, TG and APN of patients in two groups all improved significantly before and after treatment, and in the aspect of TG and APN improvement, the treatment group was better than the control group （P〈0.05）. Conclu-sion：The effect of the combination of KuGua capsule and western medicine for improving insulin resistance in pa-tients with T2DM is better than that of western medicine only.