文献类型：期刊文献

中文题名：柴胡皂苷D对肝病防治作用及机制研究进展

英文题名：Research progress of saikosaponin D on prevention and treatment of liver disease and its mechanism

作者：杨新荣[1,2,3];窦霞[3];李国峰[1,2];宋沁洁[1,2];李咸慰[1,2];吴红伟[1,2];李东辉[1,2];李越峰[1,2]

第一作者：杨新荣

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省中药制药工艺工程研究中心,甘肃兰州730000;[3]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2022

卷号：53

期号：12

起止页码：3852

中文期刊名：中草药

外文期刊名：Chinese Traditional and Herbal Drugs

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金资助项目(81460611);国家自然科学基金资助项目(81960713);国家自然科学基金资助项目(82160750);甘肃省教育厅产业支撑计划项目(2021CYZC-21);甘肃省中药制药工艺工程研究中心开放课题(ZYGY202003);科技创新服务平台建设项目-甘肃省道地中药材种质资源库(18JR2TA017);中央引导地方科技发展专项资金项目-甘肃本草众智中医药文化传承创新创业试验实践基地(30440323);甘肃省高等学校产业支撑计划项目-四种道地陇药绿色规范化产业发展示范推广(2020C-09);民生科技专项(科技特派员专题)-中药材引种驯化与道地药材产业化扶贫示范推广(20CX9NA070)。

语种：中文

中文关键词：柴胡皂苷D;肝脏炎症;肝脏损伤;肝脏代谢;作用机制

外文关键词：saikosaponin D;liver inflammation;liver injury;liver metabolism;mechanism of action

摘要：肝病的科学研究众多,开发防治肝病的药物是当前研究的热点。总结了近年来有关柴胡药效成分防治肝病的大量文章,发现柴胡皂苷具有治疗肝病的作用,其中柴胡皂苷D(saikosaponinD)药理活性最强,值得深入研究,但有关其防治肝病作用机制的报道较少。从柴胡皂苷D防治的常见肝病出发,对其作用机制进行总结和分析,以期为柴胡皂苷D防治肝病的深入研究和临床应用提供思路。
There are many scientific researches on liver disease, and the development of drugs for prevention and treatment of liver disease is the current research hotspot. A large number of articles on the prevention and treatment of liver diseases with the medicinal components of Chaihu(Bupleuri Radix) in recent years were summarized, and it was found that saikosaponin has the effect of treating liver disease. Among them, saikosaponin D(SS-D) has the strongest pharmacological activity and is worthy of in-depth study. There are few reports on its mechanism of prevention and treatment of liver disease. Starting from the common liver diseases prevented and treated by SS-D, the mechanism of action was summarized and analyzed, in order to provide ideas for the in-depth research and clinical application of SS-D in the prevention and treatment of liver diseases.