文献类型：期刊文献

英文题名：Obesity-Associated Cardiac Fibrosis: Mechanisms and Emerging Therapeutic Targets

作者：Zhou, Dan[1,2,3,4];Tan, Yingxin[5];Zhao, Jing[2,3,4];Wang, Shuping[1,2,3,4];Wang, Zheng[6];Bai, Ming[2,3,4];Niu, Xiaowei[2,3,4];Zhang, Zheng[2,3,4]

第一作者：Zhou, Dan

通信作者：Niu, XW[1];Zhang, Z[1];Niu, XW[2];Zhang, Z[2];Niu, XW[3];Zhang, Z[3]

机构：[1]Lanzhou Univ, Clin Med Sch 1, Lanzhou, Peoples R China;[2]Lanzhou Univ, Heart Ctr, Hosp 1, Lanzhou, Peoples R China;[3]Lanzhou Univ, Hosp 1, Gansu Prov Clin Res Ctr Cardiovasc Dis, Lanzhou, Peoples R China;[4]Lanzhou Univ, Hosp 1, Gansu Key Lab Cardiovasc Dis, Lanzhou, Peoples R China;[5]Lanzhou Univ, Hosp 1, Dept Vasc Surg, Gen Surg, Lanzhou, Peoples R China;[6]Gansu Univ Chinese Med, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Clin Med Sch 1, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Heart Ctr, Hosp 1, Lanzhou, Peoples R China;[2]corresponding author), Lanzhou Univ, Hosp 1, Gansu Prov Clin Res Ctr Cardiovasc Dis, Lanzhou, Peoples R China;[3]corresponding author), Lanzhou Univ, Hosp 1, Gansu Key Lab Cardiovasc Dis, Lanzhou, Peoples R China.

年份：2026

卷号：22

起止页码：1.0

外文期刊名：VASCULAR HEALTH AND RISK MANAGEMENT

收录：WOS:【ESCI(收录号:WOS:001686021400001)】；

基金：Funding This work was supported by grants from the Excellent Doctoral Program of Gansu Province (NO.22JR5RA890) , the Science and Technology Program of Gansu Province (NO.24JRRA293) and the Foundation for Scientific Research of the Gansu Provincial Talent Program (NO.2025QNTD27) . The funders had role in study design, data collection and analysis, decision to publish, or preparation of the paper.

语种：英文

外文关键词：obesity; cardiac fibrosis; cardiac dysfunction; inflammation; cytokine; RAAS; autophagy

摘要：Obesity and cardiovascular disease are major, globally prevalent, and closely interrelated health challenges. Cardiac fibrosis represents the common pathological endpoint of multiple cardiac diseases. This review systematically synthesizes the mechanisms underlying obesity-related cardiac fibrosis. It elaborates on how inflammatory factors, cytokines, and miRNAs, acting on adipose tissue and cardiac cells, drive a series of biological processes-including oxidative stress, activation of the renin-angiotensin-aldosterone system, autophagy dysregulation, and metabolic dysfunction-ultimately leading to obesity-associated cardiomyopathy characterized by ventricular remodeling, heart failure, and atrial fibrillation. Potential therapeutic targets for this condition are also examined. Furthermore, this review discusses potential therapeutic targets for this condition, which will provide a critical theoretical foundation for the development of novel strategies aimed at preventing or even reversing obesity-related fibrotic heart disease.