文献类型：期刊文献

中文题名：1990—2019年中国消化性溃疡疾病负担及变化趋势分析

英文题名：Analysis of disease burden and changing trend of peptic ulcer in China from 1990 to 2019

作者：李娜[1];汪哲[1];包云丽[1];唐海茹[1];马俊[2];郑英[3];于晓辉[3]

第一作者：李娜

机构：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000;[2]中国人民解放军联勤保障部队第九四〇医院基础医学实验室,甘肃省干细胞与基因药物重点实验室;[3]中国人民解放军联勤保障部队第九四〇医院消化内科

第一机构：甘肃中医药大学临床医学院

年份：2023

卷号：50

期号：17

起止页码：3090

中文期刊名：现代预防医学

外文期刊名：Modern Preventive Medicine

收录：CSTPCD;;北大核心:【北大核心2020】；

基金：甘肃省科技厅重点研发计划(20YF8FA099);甘肃省非感染性肝病临床医学研究中心(21JR7RA017);兰州市人才创新项目(2020-RC-111)。

语种：中文

中文关键词：消化性溃疡;疾病负担;变化趋势;Joinpoint回归分析;中国

外文关键词：Peptic ulcer;Disease burden;Changing trend;Join point regression analysis;China

摘要：目的分析中国1990—2019年消化性溃疡疾病负担及变化趋势,以完善其防治策略。方法基于2019年全球疾病负担数据库,分析中国1990—2019年消化性溃疡发病、患病、死亡、伤残调整寿命年(DALYs)及其标化率等数据,并利用Joinpoint 4.9.1.0软件通过Joinpoint回归模型分析相应的变化趋势。结果(1)1990—2019年中国消化性溃疡标化发病率、标化患病率、标化死亡率及标化DALYs率的AAPC值分别为-2.15(t=-30.397,P<0.001)、-2.09(t=-23.129,P<0.001)、-3.95(t=-34.922,P<0.001)、-4.55(t=-50.436,P<0.001),表明各指标整体均呈现为下降趋势。其中,1995—2004年之间标化发病率和标化患病率APC值分别为-3.88(t=-62.837,P<0.001)、-3.93(t=-51.061,P<0.001),下降幅度最大,并从2014年开始呈现出上升趋势。1999—2004年阶段标化死亡率出现小幅度的上升波动,标化DALYs率下降趋势明显减缓,2004年开始标化死亡率和标化DALYs率再次呈现出大幅度下降趋势,而2008年以后下降趋势有所减缓。(2)1990—2019年我国消化性溃疡疾病负担男性显著高于女性,其中2019年的标化发病率、标化患病率、标化死亡率、标化DALYs率男性分别是女性的1.73、1.73、2.13和2.33倍。(3)1990—2019年我国消化性溃疡各年龄组人群的疾病负担整体呈下降趋势,其发病、患病、死亡及DALYs均随着年龄的增长而升高,60岁以上的老年人群是疾病负担主要群体。结论1990—2019年中国消化性溃疡疾病负担下降,防治效果显著,但近年来发病和患病出现升高趋势,需进一步完善防治策略。
Objective To analyze the disease burden and changing trend of peptic ulcer in China from 1990 to 2019 in order to improve its prevention and treatment strategy.Methods Based on the global disease burden database in 2019,the incidence,disease,death,and disability adjusted life years(DALYs)and their standardized rates of peptic ulcer in China from 1990 to 2019 were analyzed,and the corresponding change trends were analyzed by Join point regression model using Joinpoint4.9.1.0 software.Results(1)The AAPC values of standardized incidence rate,standardized morbidity rate,standardized mortality rate,and standardized DALYs rate of peptic ulcer in China from 1990 to 2019 were-2.15(t=-30.397,P<0.001),-2.019(t=23.129,P<0.001),-3.95(t=-34.922,P<0.001),and-4.55(50.436,P<0.001),respectively,indicating that all indexes showed a downward trend.Among them,the APC values of standardized incidence and standardized prevalence from 1995 to 2004 were-3.88(t=-62.837,P<0.001)and-3.93(t=-51.061,P<0.001),respectively,showing an upward trend since 2014.The standardized mortality rate showed a small upward fluctuation in 1999 and 2004,and the downward trend of standardized DALYs rate slowed down obviously in 1999.The standardized mortality rate and standardized DALYs rate showed a significant downward trend again in 2004,but slowed down after 2008.(2)From 1990 to 2019,the disease burden of peptic ulcer in males was significantly higher than that in females.The standardized incidence,standardized morbidity,standardized mortality,and standardized DALYs rate in 2019 in males were 1.73,1.73,2.13,and 2.33 times higher than those in females,respectively.(3)From 1990 to 2019,the disease burden of peptic ulcers of all age groups in China showed a downward trend,and the incidence,disease,death,and DALYs increased with the increase of age.The elderly people over 60 years old made up the main groups of disease burden.Conclusion The disease burden of peptic ulcer in China decreased from 1990 to 2019,showing significant prevention and treatment effect.However,the incidence and disease prevalence have increased in recent years,so it is necessary to further improve the prevention and treatment strategy.