文献类型：期刊文献

英文题名：Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study

作者：Jia, Longfei[1,2];Du, Yifeng[3];Chu, Lan[4];Zhang, Zhanjun[5];Li, Fangyu[1,2];Lyu, Diyang[1,2];Li, Yan[1,1,2,2,13];Zhu, Min[1,2];Jiao, Haishan[1,2];Song, Yang[1,2];Shi, Yuqing[1,2];Zhang, Heng[1,2];Gong, Min[1,2];Wei, Cuibai[1,2];Tang, Yi[1,2];Fang, Boyan[6];Guo, Dongmei[1,2];Wang, Fen[1,2];Zhou, Aihong[1,2];Chu, Changbiao[1,2];Zuo, Xiumei[1,2];Yu, Yueyi[1,2];Yuan, Quan[1,2];Wang, Wei[1,2];Li, Fang[7];Shi, Shengliang[8];Yang, Heyun[9];Zhou, Chunkui[10];Liao, Zhengluan[11];Lv, Yan[12];Li, Yang;Kan, Minchen[14];Zhao, Huiying[15];Wang, Shan[16];Yang, Shanshan[17];Li, Hao[18];Liu, Zhongling[19];Wang, Qi[1,2];Qin, Wei[1,2];Jia, Jianping[1,2,20,21,22]

第一作者：Jia, Longfei

通信作者：Jia, JP[1];Jia, JP[2]

机构：[1]Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Innovat Ctr Neurol Disorders, Beijing 100053, Peoples R China;[2]Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Dept Neurol, Beijing 100053, Peoples R China;[3]Shandong Univ, Cheeloo Coll Med, Shandong Prov Hosp, Dept Neurol, Shandong, Peoples R China;[4]Guizhou Med Univ, Affiliated Hosp, Dept Neurol, Guiyang, Guizhou, Peoples R China;[5]Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China;[6]Capital Med Univ, Beijing Rehabil Hosp, Parkinson Med Ctr, Beijing, Peoples R China;[7]Capital Med Univ, Fuxing Hosp, Dept Geriatr, Beijing, Peoples R China;[8]Guangxi Med Univ, Affiliated Hosp 2, Dept Neurol, Nanning, Peoples R China;[9]First Hosp Kunming, Dept Neurol, Kunming, Yunnan, Peoples R China;[10]First Hosp Jilin Univ, Dept Neurol, Jilin, Jilin, Peoples R China;[11]Zhejiang Prov Peoples Hosp, Dept Psychiat, Hangzhou, Zhejiang, Peoples R China;[12]Hainan Gen Hosp, Dept Neurol, Haikou, Hainan, Peoples R China;[13]Shanxi Med Univ, Hosp 1, Dept Neurol, Taiyuan, Shanxi, Peoples R China;[14]Handan Cent Hosp, Dept Neurol, Handan, Hebei, Peoples R China;[15]Shijiazhuang City Hosp, Dept Neurol, Shijiazhuang, Hebei, Peoples R China;[16]Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Hebei, Peoples R China;[17]Dating Oilfield Gen Hosp, Dept Neurol, Daqing, Peoples R China;[18]First Peoples Hosp Yibin, Dept Neurol, Yibin, Sichuan, Peoples R China;[19]Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Neurol, Lanzhou, Gansu, Peoples R China;[20]Beijing Key Lab Geriatr Cognit Disorders, Beijing, Peoples R China;[21]Capital Med Univ, Clin Ctr Neurodegenerat Dis & Memory Impairment, Beijing, Peoples R China;[22]Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing, Peoples R China

第一机构：Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Innovat Ctr Neurol Disorders, Beijing 100053, Peoples R China

通信机构：[1]corresponding author), Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Innovat Ctr Neurol Disorders, Beijing 100053, Peoples R China;[2]corresponding author), Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Dept Neurol, Beijing 100053, Peoples R China.

年份：2020

卷号：5

期号：12

起止页码：E661

外文期刊名：LANCET PUBLIC HEALTH

收录：;WOS:【SSCI(收录号:WOS:000596195300010)，SCI-EXPANDED(收录号:WOS:000596195300010)】；

基金：Key Project of the National Natural Science Foundation of China, National Key Scientific Instrument and Equipment Development Project, Mission Program of Beijing Municipal Administration of Hospitals, Beijing Scholars Program, Beijing Brain Initiative from Beijing Municipal Science & Technology Commission, Project for Outstanding Doctor with Combined Ability of Western and Chinese Medicine, and Beijing Municipal Commission of Health and Family Planning.

语种：英文

摘要：Background China has a large population of older people, but has not yet undertaken a comprehensive study on the prevalence, risk factors, and management of both dementia and mild cognitive impairment (MCI). Methods For this national cross-sectional study, 46 011 adults aged 60 years or older were recruited between March 10, 2015, and Dec 26, 2018, using a multistage, stratified, cluster-sampling method, which considered geographical region, degree of urbanisation, economic development status, and sex and age distribution. 96 sites were randomly selected in 12 provinces and municipalities representative of all socioeconomic and geographical regions in China. Participants were interviewed to obtain data on sociodemographic characteristics, lifestyle, medical history, current medications, and family history, and then completed a neuropsychological testing battery administered by a psychological evaluator. The prevalence of dementia (Alzheimer's disease, vascular dementia, and other dementias) and MCI were calculated and the risk factors for different groups were examined using multivariable-adjusted analyses. Findings Overall age-adjusted and sex-adjusted prevalence was estimated to be 60% (95% CI 58-63) for dementia, 39% (38-41) for Alzheimer's disease, 16% (15-17) for vascular dementia, and 05% (05-06) for other dementias. We estimated that 1507 million (95% CI 1453-1562) people aged 60 years or older in China have dementia: 983 million (939-1029) with Alzheimer's disease, 392 million (364-422) with vascular dementia, and 132 million (116-150) with other dementias. Overall MCI prevalence was estimated to be 155% (152-159), representing 3877 million (3795-3962) people in China. Dementia and MCI shared similar risk factors including old age (dementia: odds ratios ranging from 269 [95% CI 243-298] to 660 [524-832]; MCI: from 189 [177-200] to 470 [377-587]); female sex (dementia: 143 [131-156]; MCI: 151 [143-159]); parental history of dementia (dementia: 720 [568-912]; MCI:191 [148-246]); rural residence (dementia:116 [106-127]; MCI:145 [138-154]); fewer years of education (dementia: from 117 [106-129] to 155 [138-173]; MCI: from 148 [139-158] to 348 [325-373]); being widowed, divorced, or living alone (dementia: from 259 [230-290] to 266 [229-310]; MCI: from 158 [144-173] to 174 [156-195]); smoking (dementia: 185 [167-204]; MCI: 127 [119-136]), hypertension (dementia: 186 [170-203]; MCI: 162 [154-171] for MCI), hyperlipidaemia (dementia: 187 [171-205]; MCI: 129 [121-137]), diabetes (dementia: 214 [196-234]; MCI: 144 [135-153]), heart disease (dementia: 198 [173-226]; MCI: 117 [106-130]), and cerebrovascular disease (dementia: 544 [495-597]; MCI: 149 [136-162]). Nine of these risk factors are modifiable. Interpretation Dementia and MCI are highly prevalent in China and share similar risk factors. A prevention strategy should be developed to target the identified risk factors in the MCI population to thwart or slow down disease progression. It is also crucial to optimise the management of dementia and MCI as an important part of China's public health system.