文献类型：期刊文献

英文题名：Obesity, chronic breast inflammation and carcinogenesis: Molecular pathways and clinical implications (Review)

作者：Li, Fangying[1,2];Gao, Zhenhua[2]

第一作者：Li, Fangying;李富云

通信作者：Gao, ZH[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]First Peoples Hosp Baiyin, Dept Gen Surg, 222 Silong Rd, Baiyin 730900, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), First Peoples Hosp Baiyin, Dept Gen Surg, 222 Silong Rd, Baiyin 730900, Gansu, Peoples R China.

年份：2026

卷号：68

期号：1

外文期刊名：INTERNATIONAL JOURNAL OF ONCOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001630013900001)】；

基金：Not applicable.

语种：英文

外文关键词：obesity; chronic breast inflammation; breast carcinogenesis; adipokines; insulin resistance; NF-kappa B pathway; prognostic biomarkers; weight loss interventions

摘要：Obesity is a global epidemic strongly associated with increased breast cancer (BC) risk and mortality, particularly in postmenopausal women. Obesity-induced chronic breast inflammation drives carcinogenesis via dysregulated adipokine signaling (leptin and adiponectin), insulin resistance, hyperinsulinemia and pro-inflammatory cytokines (TNF-alpha and IL-6). These factors activate oncogenic pathways (NF-kappa B and PI3K/AKT/mTOR pathways), which promote DNA damage, cell proliferation and immunosuppression. Clinically, obesity is associated with advanced tumor presentation, reduced treatment efficacy and poorer survival compared with those of normal-weight patients with BC. Despite progress, the molecular interactions between obesity-related inflammation and BC remain incompletely understood, and diagnostic/prognostic tools for obese patients require refinement. The present review synthesizes current evidence on obesity-BC mechanisms and their clinical translation to inform prevention and precision oncology strategies.